HAK5 high affinity K+ transporter 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HAK5
Official Full Name: high affinity K+ transporter 5
Primary source: TAIR:AT4G13420
Locus tag: AT4G13420
See related: Araport:AT4G13420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA HIGH AFFINITY K+ TRANSPORTER 5; ATHAK5; high affinity K+ transporter 5; T9E8.160; T9E8_160
Summary: Encodes a protein of the KUP/HAK/KT potassium channel class that is upregulated in the roots by K levels.
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Genomic context

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See HAK5 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (7796782..7802251, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis HAK5 under low K[+] availability operates as PMF powered high-affinity K[+] transporter.
Title: Arabidopsis HAK5 under low K(+) availability operates as PMF powered high-affinity K(+) transporter.
Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.
Title: Arabidopsis K+ transporter HAK5-mediated high-affinity root K+ uptake is regulated by protein kinases CIPK1 and CIPK9.
AKT1 and AtHak5 are associated with both uptake and translocation of Potassium in Arabidopsis.
Title: Modulation of K(+) translocation by AKT1 and AtHAK5 in Arabidopsis plants.
results demonstrate that ARF2 plays important roles in the response to external K(+) supply in Arabidopsis and regulates HAK5 transcription accordingly.
Title: Phosphorylation of ARF2 Relieves Its Repression of Transcription of the K+ Transporter Gene HAK5 in Response to Low Potassium Stress.
ILK1 interacted with and promoted the accumulation of HAK5, a putative (H(+))/K(+) symporter that mediates a high-affinity uptake during K(+) deficiency.[ILK1]
Title: The Raf-like Kinase ILK1 and the High Affinity K+ Transporter HAK5 Are Required for Innate Immunity and Abiotic Stress Response.
Data show that Arabidopsis Mutants lacking CBL-interacting protein kinase23 (CIPK23) are deficient in high-affinity K(+) transporter5 (HAK5)-mediated high-affinity potassium (K(+)) uptake.
Title: The CBL-Interacting Protein Kinase CIPK23 Regulates HAK5-Mediated High-Affinity K+ Uptake in Arabidopsis Roots.
On the one hand the existence of a posttranscriptional regulation of HAK5 elicited by the low K(+) signal and on the other that HAK5 may be involved in yet-unknown functions related to NO(3)(-) and P deficiencies.
Title: A low K+ signal is required for functional high-affinity K+ uptake through HAK5 transporters.
Lack of ETO1 function leads to significant enhancement of tissue K status by an RBOHF-independent mechanism associated with elevated high-affinity K(+) TRANSPORTER5 transcript levels.
Title: An Arabidopsis soil-salinity-tolerance mutation confers ethylene-mediated enhancement of sodium/potassium homeostasis.
HAK5 and four transcriptin factor genes DDF2, JLO, bHLH121 and TFII_A were highly up-regulated in response to both -K and salt stress.
Title: Identification and characterization of transcription factors regulating Arabidopsis HAK5.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
Title: Capacity and plasticity of potassium channels and high-affinity transporters in roots of barley and Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

MASC_STS12505 (e-PCR)
- UniSTS:258548

NM_117416.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables potassium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:sodium symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: high affinity K+ transporter 5

NP_567404.1

high affinity K+ transporter 5 (HAK5); FUNCTIONS IN: potassium ion transmembrane transporter activity, potassium:sodium symporter activity; INVOLVED IN: potassium ion transport; LOCATED IN: membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Potassium uptake protein, kup (InterPro:IPR018519), K+ potassium transporter (InterPro:IPR003855); BEST Arabidopsis thaliana protein match is: Potassium transporter family protein (TAIR:AT1G60160.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7796782..7802251 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117416.3 → NP_567404.1 high affinity K+ transporter 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567404.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M7K4, Q9T0L3

UniProtKB/TrEMBL

A0A5S9XRW8, Q53XI1

Conserved Domains (1) summary

cl15781
Location:2 → 783

K_trans; K+ potassium transporter