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    CYP83A1 cytochrome P450, family 83, subfamily A, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827011, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP83A1
    Official Full Name
    cytochrome P450, family 83, subfamily A, polypeptide 1
    Primary source
    TAIR:AT4G13770
    Locus tag
    AT4G13770
    See related
    Araport:AT4G13770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; CYTOCHROME P450 MONOOXYGENASE; F18A5.160; F18A5_160; family 83; polypeptide 1; polypeptide 1''; REDUCED EPIDERMAL FLUORESCENCE 2; REF2; subfamily A
    Summary
    Encodes a cytochrome p450 enzyme that catalyzes the initial conversion of aldoximes to thiohydroximates in the synthesis of glucosinolates not derived from tryptophan. Also has a role in auxin homeostasis.
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    Genomic context

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    See CYP83A1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (7990429..7992429, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS Neighboring gene SAUR-like auxin-responsive protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP83A1 is required for metabolic compatibility of Arabidopsis with the adapted powdery mildew fungus Erysiphe cruciferarum. Weis C, et al. New Phytol, 2014 Jun. PMID 24602105
    2. CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis. Naur P, et al. Plant Physiol, 2003 Sep. PMID 12970475, Free PMC Article
    3. The involvement of two p450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis. Bak S, et al. Plant Physiol, 2001 Sep. PMID 11553739, Free PMC Article
    4. Co-immunoprecipitation-based identification of putative BAX INHIBITOR-1-interacting proteins involved in cell death regulation and plant-powdery mildew interactions. Weis C, et al. Mol Plant Pathol, 2013 Oct. PMID 23782494, Free PMC Article
    5. Water stress and aphid feeding differentially influence metabolite composition in Arabidopsis thaliana (L.). Mewis I, et al. PLoS One, 2012. PMID 23144921, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of CYP83A1 changes the metabolic composition of Arabidopsis in a manner that greatly influences the interaction outcome with biotrophic and necrotrophic ascomycetes.
      Title: CYP83A1 is required for metabolic compatibility of Arabidopsis with the adapted powdery mildew fungus Erysiphe cruciferarum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117451.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome P450, family 83, subfamily A, polypeptide 1
    NP_193113.1
    • ''cytochrome P450, family 83, subfamily A, polypeptide 1'' (CYP83A1); CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 83, subfamily B, polypeptide 1 (TAIR:AT4G31500.1); Has 34068 Blast hits to 33780 proteins in 1716 species: Archae - 47; Bacteria - 3729; Metazoa - 12111; Fungi - 7377; Plants - 9632; Viruses - 3; Other Eukaryotes - 1169 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7990429..7992429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117451.4 → NP_193113.1  cytochrome P450, family 83, subfamily A, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24429, P48421
      UniProtKB/TrEMBL
      A0A178UZS6, A0A5S9XSB8, A0A7G2F0G9
      Conserved Domains (1) summary
      PLN02966
      Location:1 → 502
      PLN02966; cytochrome P450 83A1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48421.2

    Gene LinkOut

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