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    BAM3 Leucine-rich receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827774, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BAM3
    Official Full Name
    Leucine-rich receptor-like protein kinase family protein
    Primary source
    TAIR:AT4G20270
    Locus tag
    AT4G20270
    See related
    Araport:AT4G20270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BARELY ANY MERISTEM 3; F1C12.190; F1C12_190
    Summary
    Encodes a CLAVATA1-related receptor kinase-like protein required for both shoot and flower meristem function. It has a broad expression pattern and is involved in vascular strand development in the leaf, control of leaf shape, size and symmetry, male gametophyte development and ovule specification and function.
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    Genomic context

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    See BAM3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (10949573..10953113)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene TBP-associated factor 11 Neighboring gene uncharacterized protein Neighboring gene Serine/Threonine-kinase, putative (DUF1639)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutathionylation Inhibits the Catalytic Activity of Arabidopsis β-Amylase3 but Not That of Paralog β-Amylase1. Storm AR, et al. Biochemistry, 2018 Feb 6. PMID 29309132
    2. Suppression of Arabidopsis protophloem differentiation and root meristem growth by CLE45 requires the receptor-like kinase BAM3. Depuydt S, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569225, Free PMC Article
    3. The CLAVATA1-related BAM1, BAM2 and BAM3 receptor kinase-like proteins are required for meristem function in Arabidopsis. DeYoung BJ, et al. Plant J, 2006 Jan. PMID 16367950
    4. β-Amylase1 and β-amylase3 are plastidic starch hydrolases in Arabidopsis That Seem to Be Adapted for Different Thermal, pH, and stress conditions. Monroe JD, et al. Plant Physiol, 2014 Dec. PMID 25293962, Free PMC Article
    5. Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature. Hazak O, et al. EMBO Rep, 2017 Aug. PMID 28607033, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BAM3 protein levels remained unchanged under cold stress. Sodium nitroprusside, which releases NO, caused a decline in BAM3.Treatment of recombinant BAM3 with GSNO caused significant, dose-dependent inhibition of BAM3 activity. In vitro BAM3 inhibition was caused by glutathionylation at cysteine 433. The decrease in BAM3 activity under cold stress may be a result of post-translational nitroso- or glutathionylation.
      Title: Glutathionylation Inhibits the Catalytic Activity of Arabidopsis β-Amylase3 but Not That of Paralog β-Amylase1.
    2. study uncovers BAM3 as the CLE45 receptor in the root and biochemically map its peptide binding surface; CRN stabilizes BAM3 expression and is required for BAM3-mediated CLE45 signaling
      Title: Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature.
    3. Amino acid composition of BAM1 and BAM3 orthologs reflected differences that are consistent with known adaptations of proteins from heat- and cold-adapted organisms, suggesting that the day- and night-active enzymes have undergone thermal adaptation.
      Title: β-Amylase1 and β-amylase3 are plastidic starch hydrolases in Arabidopsis That Seem to Be Adapted for Different Thermal, pH, and stress conditions.
    4. Suppression of Arabidopsis protophloem differentiation and root meristem growth by CLE45 requires the receptor-like kinase BAM3.
      Title: Suppression of Arabidopsis protophloem differentiation and root meristem growth by CLE45 requires the receptor-like kinase BAM3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118146.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptide receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral organ development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of root meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phloem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich receptor-like protein kinase family protein
    NP_193760.1
    • BARELY ANY MERISTEM 3 (BAM3); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: regulation of meristem growth, protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, leaf development, floral organ development; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich receptor-like protein kinase family protein (TAIR:AT5G65700.2); Has 219938 Blast hits to 139586 proteins in 4977 species: Archae - 151; Bacteria - 21929; Metazoa - 70277; Fungi - 10656; Plants - 90391; Viruses - 423; Other Eukaryotes - 26111 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10949573..10953113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118146.5 → NP_193760.1  Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGQ6, O65440
      UniProtKB/TrEMBL
      A0A178V066
      Conserved Domains (5) summary
      PLN00113
      Location:37 → 986
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd00116
      Location:270 → 574
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:79 → 102
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:34 → 72
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:716 → 984
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65440.3

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