CTF7 protein CTF7 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CTF7
Official Full Name: protein CTF7
Primary source: TAIR:AT4G31400
Locus tag: AT4G31400
See related: Araport:AT4G31400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtCTF7; CHROMOSOME TRANSMISSION FIDELITY 7; ECO1; F3L17.7
Summary: Encodes CTF7, a homolog of the yeast CTF protein required for the formation of sister chromatid cohesion. Arabidopsis CTF7 is similar to Saccharomyces cerevisiae CTF7 in that it lacks an N-terminal extension, exhibits acetyltransferase activity, and can complement a yeast ctf7 temperature-sensitive mutation. Arabidopsis CTF7 is critical for female gametophyte and embryo development, but not for the establishment of mitotic cohesion during microgametogenesis or during endosperm development.
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Genomic context

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See CTF7 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (15237191..15239323)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

affects cytosine methylation, especially symmetric CG methylation, and expression of the copia28 retrotransposon
Title: Reduced activity of Arabidopsis chromosome-cohesion regulator gene CTF7/ECO1 alters cytosine methylation status and retrotransposon expression.
High level expression of AtCTF7 mutant proteins disrupts megasporogenesis, megagametogenesis and male meiosis, as well as causing a broad range of vegetative defects, including dwarfism that are inherited in a non-Mendelian fashion.
Title: Overexpression of a truncated CTF7 construct leads to pleiotropic defects in reproduction and vegetative growth in Arabidopsis.
we show that mutations in AtWAPL suppress the lethality associated with inactivation of AtCTF7
Title: Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis.
Arabidopsis CTF7/ECO1 plays important roles in the preservation of genome integrity and meiosis.
Title: Arabidopsis CHROMOSOME TRANSMISSION FIDELITY 7 (AtCTF7/ECO1) is required for DNA repair, mitosis and meiosis.
CTF7 is required for establishment of sister chromatid cohesion and association of cohesin with chromatin during meiosis.
Title: AtCTF7 is required for establishment of sister chromatid cohesion and association of cohesin with chromatin during meiosis in Arabidopsis.
Seeds containing T-DNA insertions in CTF7 exhibit embryo lethality early in development, while the endosperm develops normally. Overexpression of CTF7 blocked female gametophyte development.
Title: Proper levels of the Arabidopsis cohesion establishment factor CTF7 are essential for embryo and megagametophyte, but not endosperm, development.

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General gene information

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NM_001342077.1

Supported by ESTs:

NM_119289.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anther development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental vegetative growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of meiotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf phyllotactic patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: protein CTF7

NP_194868.2

CTF7; FUNCTIONS IN: damaged DNA binding, DNA-directed DNA polymerase activity; INVOLVED IN: sister chromatid cohesion, embryo sac development, embryo development; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: DNA-repair protein, UmuC-like (InterPro:IPR001126); Has 328 Blast hits to 327 proteins in 141 species: Archae - 0; Bacteria - 2; Metazoa - 149; Fungi - 104; Plants - 43; Viruses - 0; Other Eukaryotes - 30 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15237191..15239323

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119289.3 → NP_194868.2 protein CTF7 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194868.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A7UL74, O49589

UniProtKB/TrEMBL

A0A178UZG9, A0A5S9XYB4

Conserved Domains (2) summary

pfam13878
Location:83 → 122

zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

pfam13880
Location:267 → 335

Acetyltransf_13; ESCO1/2 acetyl-transferase
NM_001342077.1 → NP_001328055.1 protein CTF7 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B3F6, A0A5S9XYB4, A0A654FUY7

Conserved Domains (2) summary

pfam13878
Location:83 → 122

zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

cl17182
Location:267 → 287

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate