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    CYCB1;1 CYCLIN B1;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829904, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYCB1;1
    Official Full Name
    CYCLIN B1;1
    Primary source
    TAIR:AT4G37490
    Locus tag
    AT4G37490
    See related
    Araport:AT4G37490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYC1; CYCB1; CYCLIN 1; CYCLIN B1;1; F6G17.140; F6G17_140
    Summary
    Cyclin-dependent protein kinase CYCB1;1. Functions as an effector of growth control at G2/M. Regulated by TCP20.
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    Genomic context

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    See CYCB1;1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (17621886..17624308, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding protein Neighboring gene Ribonuclease III family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. B1-type cyclins control microtubule organization during cell division in Arabidopsis. Romeiro Motta M, et al. EMBO Rep, 2022 Jan 5. PMID 34882930, Free PMC Article
    2. ANAPHASE PROMOTING COMPLEX/CYCLOSOME-mediated cyclin B1 degradation is critical for cell cycle synchronization in syncytial endosperms. Guo L, et al. J Integr Plant Biol, 2018 Jun. PMID 29424475
    3. The APC/C subunit 10 plays an essential role in cell proliferation during leaf development. Eloy NB, et al. Plant J, 2011 Oct. PMID 21711400
    4. Overexpression of the Arabidopsis anaphase promoting complex subunit CDC27a increases growth rate and organ size. Rojas CA, et al. Plant Mol Biol, 2009 Oct. PMID 19629716
    5. Arabidopsis TCP20 links regulation of growth and cell division control pathways. Li C, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16123132, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B1-type cyclins control microtubule organization during cell division in Arabidopsis.
      Title: B1-type cyclins control microtubule organization during cell division in Arabidopsis.
    2. APC/C-mediated cyclin B1 degradation is critical for cell cycle synchronization.
      Title: ANAPHASE PROMOTING COMPLEX/CYCLOSOME-mediated cyclin B1 degradation is critical for cell cycle synchronization in syncytial endosperms.
    3. The authors identify the plant-specific B1-type CDKs (CDKB1s) and the class of B1-type cyclins (CYCB1s) as major regulators of homology-dependent repair in plants.
      Title: The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.
    4. The increased leaf size was found to be due to enhanced rates of cell division during the early stages of leaf development and by increased APC/C activity as measured by an amplification of the proteolysis rate of the mitotic cyclin, CYCB1;1.
      Title: The APC/C subunit 10 plays an essential role in cell proliferation during leaf development.
    5. APC/C is an integrator that regulates both microRNA-mediated transcriptional regulation of CYCB1;1 and degradation of CYCB1;1.
      Title: The anaphase-promoting complex is a dual integrator that regulates both MicroRNA-mediated transcriptional regulation of cyclin B1 and degradation of Cyclin B1 during Arabidopsis male gametophyte development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119913.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CYCLIN B1;1
    NP_195465.1
    • CYCLIN B1;1 (CYCB1;1); FUNCTIONS IN: cyclin-dependent protein kinase regulator activity; INVOLVED IN: regulation of cell cycle, regulation of cell growth, response to gamma radiation; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin, A/B/D/E (InterPro:IPR014400), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: Cyclin family protein (TAIR:AT5G06150.1); Has 4378 Blast hits to 4375 proteins in 374 species: Archae - 0; Bacteria - 2; Metazoa - 1992; Fungi - 556; Plants - 1161; Viruses - 34; Other Eukaryotes - 633 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17621886..17624308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119913.3 → NP_195465.1  CYCLIN B1;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30183, Q08A73, Q42081
      UniProtKB/TrEMBL
      A0A178UZN5, A0A5S9XZG3
      Conserved Domains (2) summary
      cd20511
      Location:295 → 417
      CYCLIN_AtCycB-like_rpt2; second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins
      cd20567
      Location:145 → 290
      CYCLIN_AtCycB-like_rpt1; first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30183.2

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