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    APC8 anaphase-promoting complex subunit 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823970, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APC8
    Official Full Name
    anaphase-promoting complex subunit 8
    Primary source
    TAIR:AT3G48150
    Locus tag
    AT3G48150
    See related
    Araport:AT3G48150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    anaphase-promoting complex subunit 8; CDC23
    Summary
    anaphase-promoting complex or cyclosome subunit
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    Genomic context

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    See APC8 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (17779507..17782682, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine/arginine-rich splicing factor Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene B12D protein Neighboring gene DP-E2F-like 1 Neighboring gene aldehyde dehydrogenase 10A9 Neighboring gene CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis anaphase-promoting complex/cyclosome subunit 8 is required for male meiosis. Xu RY, et al. New Phytol, 2019 Oct. PMID 31230348, Free PMC Article
    2. The anaphase-promoting complex is a dual integrator that regulates both MicroRNA-mediated transcriptional regulation of cyclin B1 and degradation of Cyclin B1 during Arabidopsis male gametophyte development. Zheng B, et al. Plant Cell, 2011 Mar. PMID 21441434, Free PMC Article
    3. The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. Capron A, et al. Plant Cell, 2003 Oct. PMID 14508008, Free PMC Article
    4. Independently evolved virulence effectors converge onto hubs in a plant immune system network. Mukhtar MS, et al. Science, 2011 Jul 29. PMID 21798943, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis APC8 is required for male meiosis.
      Title: The Arabidopsis anaphase-promoting complex/cyclosome subunit 8 is required for male meiosis.
    2. Subcellular localization of APC8 is regulated during male gametophyte development.
      Title: The anaphase-promoting complex is a dual integrator that regulates both MicroRNA-mediated transcriptional regulation of cyclin B1 and degradation of Cyclin B1 during Arabidopsis male gametophyte development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339352.1
    NM_114684.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 8
    NP_190398.1
    • anaphase-promoting complex subunit 8 (APC8); FUNCTIONS IN: binding; INVOLVED IN: cell cycle, regulation of mitotic metaphase/anaphase transition; LOCATED IN: anaphase-promoting complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Cdc23 (InterPro:IPR007192), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT3G16320.1); Has 14789 Blast hits to 8989 proteins in 1164 species: Archae - 889; Bacteria - 6197; Metazoa - 2204; Fungi - 825; Plants - 603; Viruses - 0; Other Eukaryotes - 4071 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17779507..17782682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114684.5 → NP_190398.1  anaphase-promoting complex subunit 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570L3, Q93ZW8, Q9STS3
      UniProtKB/TrEMBL
      A0A178VJZ3, A0A5S9XIU8, A0A654FIA6
      Conserved Domains (4) summary
      COG0457
      Location:219 → 439
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR02917
      Location:345 → 537
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:339 → 367
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:7 → 159
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

    2. NM_001339352.1 → NP_001326941.1  anaphase-promoting complex subunit 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VJZ3, A0A1I9LQT2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STS3.1

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