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    GCP4 GAMMA-TUBULIN COMPLEX PROTEIN 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824543, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCP4
    Official Full Name
    GAMMA-TUBULIN COMPLEX PROTEIN 4
    Primary source
    TAIR:AT3G53760
    Locus tag
    AT3G53760
    See related
    Araport:AT3G53760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGCP4; GAMMA-TUBULIN COMPLEX PROTEIN 4
    Summary
    Encodes GCP4 (gamma-Tubulin Complex Protein 4), required for microtubule organization.
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    Genomic context

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    See GCP4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (19917788..19922512, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L36e family protein Neighboring gene actin 3 Neighboring gene late embryogenesis abundant 3 (LEA3) family protein Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of the protein GCP4 on gametophyte development in Arabidopsis thaliana. Ma D, et al. Protoplasma, 2021 May. PMID 33155064
    2. The {gamma}-tubulin complex protein GCP4 is required for organizing functional microtubule arrays in Arabidopsis thaliana. Kong Z, et al. Plant Cell, 2010 Jan. PMID 20118227, Free PMC Article
    3. Feeding cells induced by phytoparasitic nematodes require γ-tubulin ring complex for microtubule reorganization. Banora MY, et al. PLoS Pathog, 2011 Dec. PMID 22144887, Free PMC Article
    4. Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex. Nakamura M, et al. Plant J, 2012 Jul. PMID 22404201
    5. The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability. Janski N, et al. Plant Cell, 2012 Mar. PMID 22427335, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of the protein GCP4 on gametophyte development in Arabidopsis thaliana.
      Title: Effects of the protein GCP4 on gametophyte development in Arabidopsis thaliana.
    2. GCP4 is an indispensable component for the function of gamma-tubulin in microtubule nucleation and organization in plant cells. [GCP4]
      Title: The {gamma}-tubulin complex protein GCP4 is required for organizing functional microtubule arrays in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115236.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to nematode IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tubulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GAMMA-TUBULIN COMPLEX PROTEIN 4
    NP_190944.2
    • GAMMA-TUBULIN COMPLEX PROTEIN 4 (GCP4); CONTAINS InterPro DOMAIN/s: Spc97/Spc98 (InterPro:IPR007259); BEST Arabidopsis thaliana protein match is: spindle pole body component 98 (TAIR:AT5G06680.1); Has 1249 Blast hits to 1181 proteins in 191 species: Archae - 0; Bacteria - 0; Metazoa - 551; Fungi - 320; Plants - 155; Viruses - 0; Other Eukaryotes - 223 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19917788..19922512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339630.1 → NP_001325627.1  GAMMA-TUBULIN COMPLEX PROTEIN 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLT8, A0A5S9XKK6, A0A654FIG6

    2. NM_001339631.1 → NP_001325626.1  GAMMA-TUBULIN COMPLEX PROTEIN 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLT7, A0A5S9XKK6, A0A654FIG6

    3. NM_115236.4 → NP_190944.2  GAMMA-TUBULIN COMPLEX PROTEIN 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190944.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NLC2, Q9M350
      UniProtKB/TrEMBL
      A0A178V4Y7, A0A5S9XKK6, A0A654FIG6
      Conserved Domains (2) summary
      pfam04130
      Location:403 → 726
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:50 → 302
      GCP_N_terminal; Gamma tubulin complex component N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M350.2

    Gene LinkOut

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