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    HEMG2 Flavin containing amine oxidoreductase family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831272, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEMG2
    Official Full Name
    Flavin containing amine oxidoreductase family
    Primary source
    TAIR:AT5G14220
    Locus tag
    AT5G14220
    See related
    Araport:AT5G14220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18O22.10; F18O22_10; MATERNAL EFFECT EMBRYO ARREST 61; MEE61; PPO2
    Summary
    Encodes PPO2, a putative protoporphyrinogen oxidase based on sequence homology. Also known as MEE61 (maternal effect embryo arrest 61). mee61 mutant shows arrested endosperm development.
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    Genomic context

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    See HEMG2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (4582629..4587653, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Myzus persicae-induced lipase 1 Neighboring gene isopropylmalate dehydrogenase 1 Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes. Hedtke B, et al. Plant Physiol, 2023 May 31. PMID 36806676, Free PMC Article
    2. Cloning and characterization of a plastidal and a mitochondrial isoform of tobacco protoporphyrinogen IX oxidase. Lermontova I, et al. Proc Natl Acad Sci U S A, 1997 Aug 5. PMID 9238074, Free PMC Article
    3. Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Pagnussat GC, et al. Development, 2005 Feb. PMID 15634699
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes.
      Title: Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001203378.1
    NM_001343324.1
    NM_001343325.1
    NM_001343326.1
    NM_121426.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxygen-dependent protoporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Flavin containing amine oxidoreductase family
    NP_001190307.1
    • HEMG2; FUNCTIONS IN: oxygen-dependent protoporphyrinogen oxidase activity; INVOLVED IN: porphyrin biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: mitochondrion, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Adrenodoxin reductase (InterPro:IPR000759), Protoporphyrinogen oxidase (InterPro:IPR004572); BEST Arabidopsis thaliana protein match is: Flavin containing amine oxidoreductase family (TAIR:AT4G01690.1).
    NP_196926.2
    • HEMG2; FUNCTIONS IN: oxygen-dependent protoporphyrinogen oxidase activity; INVOLVED IN: porphyrin biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: mitochondrion, chloroplast, plastid, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Adrenodoxin reductase (InterPro:IPR000759), Protoporphyrinogen oxidase (InterPro:IPR004572); BEST Arabidopsis thaliana protein match is: Flavin containing amine oxidoreductase family (TAIR:AT4G01690.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4582629..4587653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121426.5 → NP_196926.2  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196926.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K5H8, Q8S9J1, Q9FMS9, Q9LYA7
      UniProtKB/TrEMBL
      A0A178URA2, A0A5S9Y683
      Conserved Domains (1) summary
      PLN02576
      Location:5 → 504
      PLN02576; protoporphyrinogen oxidase

    2. NM_001343325.1 → NP_001331495.1  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE58, A0A5S9Y683

    3. NM_001343324.1 → NP_001331496.1  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE27, A0A5S9Y683
      Conserved Domains (1) summary
      PLN02576
      Location:1 → 446
      PLN02576; protoporphyrinogen oxidase

    4. NM_001343326.1 → NP_001331494.1  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE27, A0A5S9Y683
      Conserved Domains (1) summary
      PLN02576
      Location:1 → 446
      PLN02576; protoporphyrinogen oxidase

    5. NM_001203378.1 → NP_001190307.1  Flavin containing amine oxidoreductase family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y683
      Conserved Domains (2) summary
      PLN02576
      Location:5 → 474
      PLN02576; protoporphyrinogen oxidase
      pfam13450
      Location:21 → 86
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S9J1.1

    Gene LinkOut

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