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    DRM1 domains rearranged methylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831390, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DRM1
    Official Full Name
    domains rearranged methylase 1
    Primary source
    TAIR:AT5G15380
    Locus tag
    AT5G15380
    See related
    Araport:AT5G15380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    domains rearranged methylase 1; F8M21.270; F8M21_270
    Summary
    Encodes methyltransferase involved in the de novo DNA methylation and maintenance of asymmetric methylation of DNA sequences.
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    Genomic context

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    See DRM1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (4991347..4994924)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA/rRNA methyltransferase (SpoU) family protein Neighboring gene U-box domain-containing protein Neighboring gene Cyclic nucleotide-regulated ion channel family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes. Cao X, et al. Proc Natl Acad Sci U S A, 2002 Dec 10. PMID 12151602, Free PMC Article
    2. Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Cao X, et al. Curr Biol, 2002 Jul 9. PMID 12121623
    3. Hypomethylated drm1 drm2 cmt3 mutant phenotype of Arabidopsis thaliana is related to auxin pathway impairment. Forgione I, et al. Plant Sci, 2019 Mar. PMID 30824017
    4. Cooperative activity of DNA methyltransferases for maintenance of symmetrical and non-symmetrical cytosine methylation in Arabidopsis thaliana. Singh A, et al. Plant J, 2008 Dec. PMID 18665914, Free PMC Article
    5. The RNA silencing enzyme RNA polymerase v is required for plant immunity. López A, et al. PLoS Genet, 2011 Dec. PMID 22242006, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The drm1 drm2 cmt3 triple mutant of Arabidopsis thaliana have novel growth disorders and are efective both in maintenance and de novo DNA methylation, which highlights the correlation between DNA methylation and the auxin hormone pathway.
      Title: Hypomethylated drm1 drm2 cmt3 mutant phenotype of Arabidopsis thaliana is related to auxin pathway impairment.
    2. Three methyltransferases MET1, CMT3 and DRM1/2 are all required cooperatively for RPS methylation both at CG and non-CG sites.
      Title: Cooperative activity of DNA methyltransferases for maintenance of symmetrical and non-symmetrical cytosine methylation in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA methylation-dependent constitutive heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    domains rearranged methylase 1
    NP_197042.2
    • domains rearranged methylase 1 (DRM1); CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), DNA methylase, C-5 cytosine-specific (InterPro:IPR001525); BEST Arabidopsis thaliana protein match is: domains rearranged methyltransferase 2 (TAIR:AT5G14620.1); Has 662 Blast hits to 554 proteins in 116 species: Archae - 0; Bacteria - 110; Metazoa - 281; Fungi - 2; Plants - 156; Viruses - 12; Other Eukaryotes - 101 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4991347..4994924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121542.3 → NP_197042.2  domains rearranged methylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197042.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6QPM0, Q9LXE5, Q9LXE6
      UniProtKB/TrEMBL
      A0A178USQ0
      Conserved Domains (2) summary
      COG0270
      Location:498 → 619
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cl21463
      Location:195 → 230
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LXE5.2

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