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    TK1b Thymidine kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832371, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TK1b
    Official Full Name
    Thymidine kinase
    Primary source
    TAIR:AT5G23070
    Locus tag
    AT5G23070
    See related
    Araport:AT5G23070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTK1b; MYJ24.6; MYJ24_6; thymidine kinase 1b
    Summary
    Encodes a thymidine kinase that salvages DNA precursors.
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    Genomic context

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    See TK1b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (7741792..7742978)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein Neighboring gene nuclear factor Y, subunit B13 Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of pyrimidine salvage pathway in the maintenance of organellar and nuclear genome integrity. Pedroza-García JA, et al. Plant J, 2019 Feb. PMID 30317699
    2. Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development. Xu J, et al. New Phytol, 2015 Dec. PMID 26139575
    3. Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase. Le Ret M, et al. Plant Physiol, 2018 Dec. PMID 30305373, Free PMC Article
    4. Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana. Clausen AR, et al. FEBS J, 2012 Oct. PMID 22897443
    5. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. Mutahir Z, et al. FEBS J, 2013 Mar. PMID 23351158

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TK1B is required for efficient chloroplast DNA replication and chloroplast biogenesis.
      Title: Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase.
    2. Findings clarify the specialized function of two TKs in A. thaliana and establish that the [nucleotide] salvage pathway mediated by the kinases is essential for plant growth and development. [AtTK2]
      Title: Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development.
    3. Data show that thymidine kinase was encoded by AtTK1a (AT3G07800) and (AT5G23070), and deoxyadenosine, deoxyguanosine and deoxycytidine kinase activities were encoded by a single AtdNK (AT1G72040) gene.
      Title: Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_122213.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thymidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seedling development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Thymidine kinase
    NP_568426.1
    • Thymidine kinase; FUNCTIONS IN: thymidine kinase activity, ATP binding; INVOLVED IN: pyrimidine deoxyribonucleoside interconversion, anaerobic respiration; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thymidine kinase (InterPro:IPR001267), Thymidine kinase, conserved site (InterPro:IPR020633); BEST Arabidopsis thaliana protein match is: Thymidine kinase (TAIR:AT3G07800.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7741792..7742978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122213.4 → NP_568426.1  Thymidine kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KBF5, Q9FN47
      UniProtKB/TrEMBL
      A0A178UCI4, A0A5S9Y705, A0A654G3I6, A0A7G2FAI5
      Conserved Domains (1) summary
      cl23762
      Location:77 → 259
      TK; Thymidine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KBF5.1

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