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    FIM5 fimbrin-like protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833544, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FIM5
    Official Full Name
    fimbrin-like protein 2
    Primary source
    TAIR:AT5G35700
    Locus tag
    AT5G35700
    See related
    Araport:AT5G35700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FIM2; fimbrin-like protein 2; FIMBRIN5; MXH1.5; MXH1_5
    Summary
    Encodes FIMBRIN5, an actin bundling factor required for pollen germination and pollen tube growth.
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    Genomic context

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    See FIM5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (13872479..13876876, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Plant thionin family protein Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis FIM5 decorates apical actin filaments and regulates their organization in the pollen tube. Zhang M, et al. J Exp Bot, 2016 May. PMID 27117336, Free PMC Article
    2. Actin-bundling protein fimbrin serves as a new auxin biosynthesis orchestrator in Arabidopsis root tips. Liu YK, et al. New Phytol, 2024 Oct. PMID 39044442
    3. Fimbrins 4 and 5 Act Synergistically During Polarized Pollen Tube Growth to Ensure Fertility in Arabidopsis. Su H, et al. Plant Cell Physiol, 2017 Nov 1. PMID 29036437
    4. Arabidopsis FIMBRIN5, an actin bundling factor, is required for pollen germination and pollen tube growth. Wu Y, et al. Plant Cell, 2010 Nov. PMID 21098731, Free PMC Article
    5. The Structurally Plastic CH2 Domain Is Linked to Distinct Functions of Fimbrins/Plastins. Zhang R, et al. J Biol Chem, 2016 Aug 19. PMID 27261463, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Actin-bundling protein fimbrin serves as a new auxin biosynthesis orchestrator in Arabidopsis root tips.
      Title: Actin-bundling protein fimbrin serves as a new auxin biosynthesis orchestrator in Arabidopsis root tips.
    2. FIM5 organizes and maintains normal actin architecture in pollen grains and pollen tubes to fulfill double fertilization in plants.
      Title: Fimbrins 4 and 5 Act Synergistically During Polarized Pollen Tube Growth to Ensure Fertility in Arabidopsis.
    3. FIM5 decorates apical actin filaments and regulates their organization in order to drive polarized pollen tube growth.
      Title: Arabidopsis FIM5 decorates apical actin filaments and regulates their organization in the pollen tube.
    4. FIM4 generates both actin bundles and cross-linked actin filaments, whereas FIM5 only generates actin bundles. The distinct functions of FIM4 and FIM5 are clearly observed at single-filament resolution.
      Title: The Structurally Plastic CH2 Domain Is Linked to Distinct Functions of Fimbrins/Plastins.
    5. Data suggest that FIMBRIN5 regulates actin dynamics and organization during pollen germination and tube growth via stabilizing actin filaments and organizing them into higher-order structures. [FIMBRIN5]
      Title: Arabidopsis FIMBRIN5, an actin bundling factor, is required for pollen germination and pollen tube growth.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_122961.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fimbrin-like protein 2
    NP_198420.1
    • fimbrin-like protein 2 (FIM2); FUNCTIONS IN: actin binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Actinin-type, actin-binding, conserved site (InterPro:IPR001589), Calponin-homology (InterPro:IPR016146), Calponin-like actin-binding (InterPro:IPR001715); BEST Arabidopsis thaliana protein match is: Actin binding Calponin homology (CH) domain-containing protein (TAIR:AT2G04750.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13872479..13876876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122961.4 → NP_198420.1  fimbrin-like protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56Z07, Q9FKI0
      UniProtKB/TrEMBL
      A0A178UMC2, A0A5S9Y8B9, A0A654G5I4
      Conserved Domains (4) summary
      cd21293
      Location:123 → 238
      CH_AtFIM_like_rpt1; first calponin homology (CH) domain found in the Arabidopsis thaliana fimbrin family
      cd21296
      Location:259 → 367
      CH_AtFIM_like_rpt2; second calponin homology (CH) domain found in the Arabidopsis thaliana fimbrin family
      cd21299
      Location:390 → 503
      CH_AtFIM_like_rpt3; third calponin homology (CH) domain found in the Arabidopsis thaliana fimbrin family
      cd21302
      Location:513 → 621
      CH_AtFIM_like_rpt4; fourth calponin homology (CH) domain found in the Arabidopsis thaliana fimbrin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKI0.1

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