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    FLS2 Leucine-rich receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834676, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLS2
    Official Full Name
    Leucine-rich receptor-like protein kinase family protein
    Primary source
    TAIR:AT5G46330
    Locus tag
    AT5G46330
    See related
    Araport:AT5G46330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FLAGELLIN-SENSITIVE 2; MPL12.13; MPL12.8; MPL12_13
    Summary
    Encodes a leucine-rich repeat serine/threonine protein kinase that is expressed ubiquitously. FLS2 is involved in MAP kinase signalling relay involved in innate immunity. Essential in the perception of flagellin, a potent elicitor of the defense response. FLS2 is directed for degradation by the bacterial ubiquitin ligase AvrPtoB.
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    Genomic context

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    See FLS2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (18791575..18795908)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene MADS-box family protein Neighboring gene tRNA-Leu Neighboring gene O-acetyltransferase family protein Neighboring gene WRKY DNA-binding protein 8 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis. Gómez-Gómez L, et al. Mol Cell, 2000 Jun. PMID 10911994
    2. Chimeric FLS2 receptors reveal the basis for differential flagellin perception in Arabidopsis and tomato. Mueller K, et al. Plant Cell, 2012 May. PMID 22634763, Free PMC Article
    3. Mapping FLS2 function to structure: LRRs, kinase and its working bits. Robatzek S, et al. Protoplasma, 2013 Jun. PMID 23053766
    4. Spatio-temporal cellular dynamics of the Arabidopsis flagellin receptor reveal activation status-dependent endosomal sorting. Beck M, et al. Plant Cell, 2012 Oct. PMID 23085733, Free PMC Article
    5. Probing the Arabidopsis flagellin receptor: FLS2-FLS2 association and the contributions of specific domains to signaling function. Sun W, et al. Plant Cell, 2012 Mar. PMID 22388452, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myosin XI-mediated BIK1 recruitment to nanodomains facilitates FLS2-BIK1 complex formation during innate immunity in Arabidopsis.
      Title: Myosin XI-mediated BIK1 recruitment to nanodomains facilitates FLS2-BIK1 complex formation during innate immunity in Arabidopsis.
    2. FLS2-RBOHD-PIF4 Module Regulates Plant Response to Drought and Salt Stress.
      Title: FLS2-RBOHD-PIF4 Module Regulates Plant Response to Drought and Salt Stress.
    3. Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors.
      Title: Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors.
    4. Chemical control of receptor kinase signaling by rapamycin-induced dimerization.
      Title: Chemical control of receptor kinase signaling by rapamycin-induced dimerization.
    5. Flg22-induced Ca(2+) increases undergo desensitization and resensitization.
      Title: Flg22-induced Ca(2+) increases undergo desensitization and resensitization.
    6. BRASSINOSTEROID-SIGNALLING KINASES 7 and 8 associate with the FLS2 immune receptor and are required for flg22-induced PTI responses.
      Title: BRASSINOSTEROID-SIGNALLING KINASES 7 and 8 associate with the FLS2 immune receptor and are required for flg22-induced PTI responses.
    7. Juxta-membrane S-acylation of plant receptor-like kinases is likely fortuitous and does not necessarily impact upon function.
      Title: Juxta-membrane S-acylation of plant receptor-like kinases is likely fortuitous and does not necessarily impact upon function.
    8. NSP-interacting kinase 1 (NIK1) negatively regulates the formation of FLAGELLIN-SENSITIVE 2 protein (FLS2) / SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 3 (BAK1) complex.
      Title: The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.
    9. Arabidopsis ORM1 and ORM2 modulate plant immunity by regulating FLS2 protein accumulation.
      Title: A Plant Immune Receptor Degraded by Selective Autophagy.
    10. Bacterial flagellin induces the conjugation of the SMALL UBIQUITIN-LIKE MODIFIER (SUMO) protein to FLS2 to trigger release of BIK1 resulting in resistant to bacterial pathogens in Arabidopsis.
      Title: SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344672.1
    NM_124003.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response by callose deposition in cell wall IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pathogen-associated molecular pattern receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich receptor-like protein kinase family protein
    NP_199445.1
    • FLAGELLIN-SENSITIVE 2 (FLS2); FUNCTIONS IN: protein serine/threonine kinase activity, transmembrane receptor protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: in 6 processes; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat, typical subtype (InterPro:IPR003591), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase (TAIR:AT4G20140.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18791575..18795908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124003.4 → NP_199445.1  Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVN3, Q84WF4, Q9FL28
      UniProtKB/TrEMBL
      A0A178UHY5, A0A5S9YCM1, C0LGU8
      Conserved Domains (5) summary
      PLN00113
      Location:8 → 1153
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd00116
      Location:293 → 564
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd14066
      Location:876 → 1156
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      sd00033
      Location:218 → 241
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:30 → 69
      LRRNT_2; Leucine rich repeat N-terminal domain

    2. NM_001344672.1 → NP_001330009.1  Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVN3, Q84WF4, Q9FL28
      UniProtKB/TrEMBL
      A0A178UHY5, A0A5S9YCM1, C0LGU8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FL28.1

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