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    CPI1 cyclopropyl isomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835105, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPI1
    Official Full Name
    cyclopropyl isomerase
    Primary source
    TAIR:AT5G50375
    Locus tag
    AT5G50375
    See related
    Araport:AT5G50375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYCLOEUCALENOL CYCLOISOMERASE; cyclopropyl isomerase
    Summary
    Converts pentacyclic cyclopropyl sterols to conventional tetracyclic sterols. CPI1 function during and just after division and support gravitropism by establishing polar PIN2 localization. Required for endocytosis of PIN2
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    Genomic context

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    See CPI1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (20511642..20514346)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Adenylate kinase family protein Neighboring gene exocyst subunit exo70 family protein F1 Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics and Endocytosis of Flot1 in Arabidopsis Require CPI1 Function. Cao Y, et al. Int J Mol Sci, 2020 Feb 25. PMID 32106431, Free PMC Article
    2. Plant cyclopropylsterol-cycloisomerase: key amino acids affecting activity and substrate specificity. Rahier A, et al. Biochem J, 2014 Apr 15. PMID 24483781
    3. Sterol-dependent endocytosis mediates post-cytokinetic acquisition of PIN2 auxin efflux carrier polarity. Men S, et al. Nat Cell Biol, 2008 Feb. PMID 18223643
    4. Functional cloning of an Arabidopsis thaliana cDNA encoding cycloeucalenol cycloisomerase. Lovato MA, et al. J Biol Chem, 2000 May 5. PMID 10788449
    5. WUSCHEL-responsive At5g65480 interacts with CLAVATA components in vitro and in transient expression. Gish LA, et al. PLoS One, 2013. PMID 23776660, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamics and Endocytosis of Flot1 in Arabidopsis Require CPI1 Function.
      Title: Dynamics and Endocytosis of Flot1 in Arabidopsis Require CPI1 Function.
    2. Mutational analysis of the CP1 amino acid sequence and its role in the enzyme's activity and substrate specificity is reported.
      Title: Plant cyclopropylsterol-cycloisomerase: key amino acids affecting activity and substrate specificity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203575.1
    NM_124419.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cycloeucalenol cycloisomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cycloeucalenol cycloisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclopropyl isomerase
    NP_001190504.1
    • cyclopropyl isomerase (CPI1); FUNCTIONS IN: cycloeucalenol cycloisomerase activity; INVOLVED IN: pinocytosis, sterol biosynthetic process, positive gravitropism, cytokinesis; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cycloeucalenol cycloisomerase (InterPro:IPR020532).
    NP_568727.1
    • cyclopropyl isomerase (CPI1); FUNCTIONS IN: cycloeucalenol cycloisomerase activity; INVOLVED IN: pinocytosis, sterol biosynthetic process, positive gravitropism, cytokinesis; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cycloeucalenol cycloisomerase (InterPro:IPR020532); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20511642..20514346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344891.1 → NP_001331972.1  cyclopropyl isomerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFJ3

    2. NM_124419.5 → NP_568727.1  cyclopropyl isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M643
      UniProtKB/TrEMBL
      A0A178UKK4, A0A384KCA7, Q1ECD0, Q56X96

    3. NM_001203575.1 → NP_001190504.1  cyclopropyl isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K8Y4, Q56X96
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M643.1

    Gene LinkOut

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