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    NMNAT nicotinate/nicotinamide mononucleotide adenyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835675, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NMNAT
    Official Full Name
    nicotinate/nicotinamide mononucleotide adenyltransferase
    Primary source
    TAIR:AT5G55810
    Locus tag
    AT5G55810
    See related
    Araport:AT5G55810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNMNAT; MDF20.25; MDF20_25; nicotinate/nicotinamide mononucleotide adenyltransferase
    Summary
    encodes a bi-functional enzyme that expresses both nicotinamide-nucleotide adenylyltransferase (2.7.7.1) and nicotinate-nucleotide adenylyltransferase (2.7.7.18)activity.
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    Genomic context

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    See NMNAT in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (22583972..22586405, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene inner centromere protein, ARK-binding region protein Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase (AtNMNAT) is required for pollen tube growth. Hashida SN, et al. Plant J, 2007 Feb. PMID 17270012
    2. Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control. Pulido P, et al. Plant Cell, 2013 Oct. PMID 24104567, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203622.1
    NM_001345151.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nicotinamide-nucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinate-nucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate/nicotinamide mononucleotide adenyltransferase
    NP_001190551.1
    • nicotinate/nicotinamide mononucleotide adenyltransferase (NMNAT); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Probable nicotinate-nucleotide adenylyltransferase (InterPro:IPR005248), Cytidylyltransferase (InterPro:IPR004820).
    NP_200392.3
    • nicotinate/nicotinamide mononucleotide adenyltransferase (NMNAT); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Probable nicotinate-nucleotide adenylyltransferase (InterPro:IPR005248), Cytidylyltransferase (InterPro:IPR004820); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22583972..22586405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124963.5 → NP_200392.3  nicotinate/nicotinamide mononucleotide adenyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200392.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K687, Q8VZB8, Q9FM58
      UniProtKB/TrEMBL
      A0A5S9YEI5
      Conserved Domains (1) summary
      PLN02945
      Location:1 → 235
      PLN02945; nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase

    2. NM_001203622.1 → NP_001190551.1  nicotinate/nicotinamide mononucleotide adenyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GBB6, F4K688
      Conserved Domains (1) summary
      cl00015
      Location:1 → 261
      nt_trans; nucleotidyl transferase superfamily

    3. NM_001345151.1 → NP_001329970.1  nicotinate/nicotinamide mononucleotide adenyltransferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9B6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4K687.1

    Gene LinkOut

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