OASB O-acetylserine (thiol) lyase B [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: OASB
Official Full Name: O-acetylserine (thiol) lyase B
Primary source: TAIR:AT2G43750
Locus tag: AT2G43750
See related: Araport:AT2G43750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACS1; ARABIDOPSIS CYSTEINE SYNTHASE 1; ARABIDOPSIS CYSTEINE SYNTHASE 1; ARABIDOPSIS THALIANA CYSTEIN SYNTHASE-B; ATCS-B; CHLOROPLAST O-ACETYLSERINE SULFHYDRYLASE 1; CPACS1; CSASE B; CYSTEINE SYNTHASE; F18O19.14; O-acetylserine (thiol) lyase B
Summary: Arabidopsis thaliana O-acetylserine (thiol) lyase (OAS-TL) isoform oasB, the key enzyme for fixation of inorganic sulfide. It catalyzes the formation of cysteine from O-acetylserine and inorganic sulfide. Required for pollen tube growth and/or fertilization.
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Genomic context

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See OASB in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (18129435..18132638, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
Title: Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis.
These results provide new insights into the molecular mechanism underlying formation of the Cys synthase complex and provide a structural basis for the biochemical regulation of Cys biosynthesis in plants.
Title: Structural basis for interaction of O-acetylserine sulfhydrylase and serine acetyltransferase in the Arabidopsis cysteine synthase complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001202816.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cysteine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double fertilization forming a zygote and endosperm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen tube growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endosome	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plastid	TAS Traceable Author Statement more info	PubMed
located_in trans-Golgi network	HDA more info	PubMed

General protein information

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Preferred Names: O-acetylserine (thiol) lyase B

NP_001189745.1

O-acetylserine (thiol) lyase B (OASB); CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase isoform C (TAIR:AT3G59760.3).

NP_181903.1

O-acetylserine (thiol) lyase B (OASB); FUNCTIONS IN: cysteine synthase activity; INVOLVED IN: response to cadmium ion, cysteine biosynthetic process; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase isoform C (TAIR:AT3G59760.3); Has 23408 Blast hits to 23391 proteins in 2708 species: Archae - 428; Bacteria - 16574; Metazoa - 458; Fungi - 677; Plants - 586; Viruses - 2; Other Eukaryotes - 4683 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18129435..18132638 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129937.4 → NP_181903.1 O-acetylserine (thiol) lyase B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181903.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22828, P47999, Q42568

UniProtKB/TrEMBL

A0A178VU69, A0A384KAY1, Q0WW95

Conserved Domains (1) summary

cl00342
Location:1 → 392

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
NM_001202816.1 → NP_001189745.1 O-acetylserine (thiol) lyase B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189745.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22828, P47999, Q42568

UniProtKB/TrEMBL

A0A178VU69, A0A384KAY1, Q0WW95

Conserved Domains (1) summary

cl00342
Location:1 → 392

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...