G4 UbiA prenyltransferase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: G4
Official Full Name: UbiA prenyltransferase family protein
Primary source: TAIR:AT3G51820
Locus tag: AT3G51820
See related: Araport:AT3G51820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATG4; CHLG; PDE325; PIGMENT DEFECTIVE 325
Summary: Encodes a protein with chlorophyll synthase activity. This enzyme has been shown to perform the esterification of chlorophyllide (a and b), the last step of chlorophyll biosynthesis. Although it can use either geranylgeranyl pyrophosphate (GGPP) or phytyl pyrophosphate (PhyPP) as substrates, the esterification reaction was faster with GGPP than with PhyPP.
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Genomic context

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See G4 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 14

Sequence:: Chromosome: 3; NC_003074.8 (19215930..19219128, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abscisic Acid-Triggered Persulfidation of the Cys Protease ATG4 Mediates Regulation of Autophagy by Sulfide.
Title: Abscisic Acid-Triggered Persulfidation of the Cys Protease ATG4 Mediates Regulation of Autophagy by Sulfide.
ATG4 Mediated Psm ES4326/AvrRpt2-Induced Autophagy Dependent on Salicylic Acid in Arabidopsis Thaliana.
Title: ATG4 Mediated Psm ES4326/AvrRpt2-Induced Autophagy Dependent on Salicylic Acid in Arabidopsis Thaliana.
Data show that leaves of RNA interference lines with partial suppression of chloriphyll synthase (CHLSYN; At3g51820) CHLSYN displayed marked reductions in chlorophyll but up to a 2-fold increase in tocopherol concentrations.
Title: Chlorophyll Synthase under Epigenetic Surveillance Is Critical for Vitamin E Synthesis, and Altered Expression Affects Tocopherol Levels in Arabidopsis.
Chlorophyll synthase acts in a salvage pathway for chlorophyll biosynthesis by re-esterifying the chlorophyllide a produced during chlorophyll turnover.
Title: Analysis of an Arabidopsis heat-sensitive mutant reveals that chlorophyll synthase is involved in reutilization of chlorophyllide during chlorophyll turnover.
AtAtg4a is the predominant protease and it processes AtAtg8a, AtAtg8c, AtAtg8d, and AtAtg8i better than AtAtg4b in vitro.
Title: Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_115041.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables chlorophyll synthetase activity	IDA Inferred from Direct Assay more info
enables chlorophyll synthetase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chlorophyll biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chlorophyll biosynthetic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid	HDA more info	PubMed
located_in chloroplast thylakoid membrane	TAS Traceable Author Statement more info	PubMed
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: UbiA prenyltransferase family protein

NP_190750.1

G4; FUNCTIONS IN: chlorophyll synthetase activity; INVOLVED IN: chlorophyll biosynthetic process; LOCATED IN: chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Bacteriochlorophyll/chlorophyll synthetase (InterPro:IPR006372), Chlorophyll synthase, ChlG (InterPro:IPR011799), UbiA prenyltransferase (InterPro:IPR000537); BEST Arabidopsis thaliana protein match is: homogentisate prenyltransferase (TAIR:AT3G11945.1); Has 2782 Blast hits to 2782 proteins in 800 species: Archae - 310; Bacteria - 1584; Metazoa - 63; Fungi - 24; Plants - 236; Viruses - 0; Other Eukaryotes - 565 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

19215930..19219128 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115041.4 → NP_190750.1 UbiA prenyltransferase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190750.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38833

UniProtKB/TrEMBL

A0A178VH65, A0A5S9XJY3, A0A654FG98, A0A7G2EQL8

Conserved Domains (1) summary

PLN00012
Location:16 → 387

PLN00012; chlorophyll synthetase; Provisional