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    MS3 methionine synthase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832223, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MS3
    Official Full Name
    methionine synthase 3
    Primary source
    TAIR:AT5G20980
    Locus tag
    AT5G20980
    See related
    Araport:AT5G20980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMS3; F22D1.150; F22D1_150; methionine synthase 3
    Summary
    encodes a plastidic methionine synthase, involved in methionine de novo synthesis in the chloroplast
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    Genomic context

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    See MS3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (7122800..7128412, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase family protein Neighboring gene aldehyde oxidase 1 Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene ncRNA Neighboring gene molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1) Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. METHIONINE SYNTHASE1 Is Involved in Chromatin Silencing by Maintaining DNA and Histone Methylation. Yan X, et al. Plant Physiol, 2019 Sep. PMID 31331996, Free PMC Article
    2. Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. Ravanel S, et al. J Biol Chem, 2004 May 21. PMID 15024005
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001085142.1
    NM_122107.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methionine synthase 3
    NP_001078611.1
    • methionine synthase 3 (MS3); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: cellular amino acid biosynthetic process, methionine biosynthetic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 4531 Blast hits to 4521 proteins in 1682 species: Archae - 195; Bacteria - 3241; Metazoa - 18; Fungi - 208; Plants - 251; Viruses - 2; Other Eukaryotes - 616 (source: NCBI BLink).
    NP_197598.2
    • methionine synthase 3 (MS3); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: cellular amino acid biosynthetic process, methionine biosynthetic process; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 4531 Blast hits to 4521 proteins in 1682 species: Archae - 195; Bacteria - 3241; Metazoa - 18; Fungi - 208; Plants - 251; Viruses - 2; Other Eukaryotes - 616 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7122800..7128412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085142.1 → NP_001078611.1  methionine synthase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNZ5, Q6KCR0
      UniProtKB/TrEMBL
      A0A178UH18, A0A5S9Y5Z7, A0A654G3L5
      Conserved Domains (3) summary
      PLN02475
      Location:49 → 812
      PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
      cd03312
      Location:50 → 414
      CIMS_N_terminal_like; CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme ...
      pfam01717
      Location:480 → 803
      Meth_synt_2; Cobalamin-independent synthase, Catalytic domain

    2. NM_122107.4 → NP_197598.2  methionine synthase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197598.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNZ5, Q6KCR0
      UniProtKB/TrEMBL
      A0A178UH18, A0A5S9Y5Z7, A0A654G3L5
      Conserved Domains (3) summary
      PLN02475
      Location:49 → 812
      PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
      cd03312
      Location:50 → 414
      CIMS_N_terminal_like; CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme ...
      pfam01717
      Location:480 → 803
      Meth_synt_2; Cobalamin-independent synthase, Catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WNZ5.1

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