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    FBX2 F-box protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832228, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FBX2
    Official Full Name
    F-box protein 2
    Primary source
    TAIR:AT5G21040
    Locus tag
    AT5G21040
    See related
    Araport:AT5G21040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F-box protein 2; T10F18.1
    Summary
    Encodes an F-box containing protein that interacts physically with BHLH32 and appears to be involved in mediating phosphate starvation responses.
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    Genomic context

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    See FBX2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (7144829..7147277, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene PAZ domain-containing protein / piwi domain-containing protein Neighboring gene hyccin Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an F-box protein that negatively regulates P(i) starvation responses. Chen ZH, et al. Plant Cell Physiol, 2008 Dec. PMID 18930958
    2. ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance. Campe R, et al. New Phytol, 2016 Jan. PMID 26315018
    3. A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins. Kuroda H, et al. PLoS One, 2012. PMID 23166809, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBX2 interacts with BHLH32, and is a negative regulator of several P(i) starvation responses.
      Title: Identification of an F-box protein that negatively regulates P(i) starvation responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203423.1
    NM_001343696.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    F-box protein 2
    NP_001190352.1
    • F-box protein 2 (FBX2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: cellular response to phosphate starvation; LOCATED IN: SCF ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), F-box domain, cyclin-like (InterPro:IPR001810), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), F-box domain, Skp2-like (InterPro:IPR022364), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G43770.1).
    NP_568408.1
    • F-box protein 2 (FBX2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), F-box domain, cyclin-like (InterPro:IPR001810), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), F-box domain, Skp2-like (InterPro:IPR022364), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G43770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7144829..7147277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122112.4 → NP_568408.1  F-box protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568408.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AD8
      UniProtKB/TrEMBL
      A0A178URR1, A0A5S9Y8B2, A0A654G2Z9, A0A7G2FCJ4
      Conserved Domains (3) summary
      cd00200
      Location:154 → 468
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:261 → 294
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:68 → 112
      F-box-like

    2. NM_001203423.1 → NP_001190352.1  F-box protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AD8
      UniProtKB/TrEMBL
      A0A178URR1, A0A5S9Y8B2, A0A654G2Z9, A0A7G2FCJ4
      Conserved Domains (3) summary
      cd00200
      Location:154 → 468
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:261 → 294
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:68 → 112
      F-box-like

    3. NM_001343696.1 → NP_001331436.1  F-box protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AD8
      UniProtKB/TrEMBL
      A0A178URR1, A0A5S9Y8B2, A0A654G2Z9, A0A7G2FCJ4
      Conserved Domains (3) summary
      cd00200
      Location:154 → 468
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:261 → 294
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:68 → 112
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AD8.1

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