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    DCP5 decapping 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839152, updated on 6-Nov-2024

    Summary

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    Official Symbol
    DCP5
    Official Full Name
    decapping 5
    Primary source
    TAIR:AT1G26110
    Locus tag
    AT1G26110
    See related
    Araport:AT1G26110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    decapping 5; F14G11.8; F14G11_8
    Summary
    Encodes Decapping 5, required for mRNA decapping, P-body formation and translational repression during postembryonic development.
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    Genomic context

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    See DCP5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (9024341..9027955, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene Cytochrome b561/ferric reductase transmembrane protein family Neighboring gene ncRNA Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene miscRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytoplasmic osmosensing mechanism mediated by molecular crowding-sensitive DCP5. Wang Z, et al. Science, 2024 Nov. PMID 39480925
    2. The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis. Scheer H, et al. Nat Commun, 2021 Feb 26. PMID 33637717, Free PMC Article
    3. The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis. Wang W, et al. Plant Cell, 2023 Sep 1. PMID 37220754, Free PMC Article
    4. Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation. Xu J, et al. EMBO J, 2012 Apr 18. PMID 22407295, Free PMC Article
    5. Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development. Xu J, et al. Plant Cell, 2009 Oct. PMID 19855049, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A cytoplasmic osmosensing mechanism mediated by molecular crowding-sensitive DCP5.
      Title: A cytoplasmic osmosensing mechanism mediated by molecular crowding-sensitive DCP5.
    2. The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis.
      Title: The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis.
    3. These results suggest that mRNA decapping through MPK6-DCP1-DCP5 pathway serves as a rapid response to dehydration stress in Arabidopsis.
      Title: Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation.
    4. In vitro experiments using wheat germ extracts confirmed that DCP5 is a translational repressor. Results showed that DCP5 is required for translational repression and P-body formation and plays an indirect role in mRNA decapping.
      Title: Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001160895.1
    NM_102376.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within P-body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within deadenylation-independent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytoplasmic mRNA processing body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    decapping 5
    NP_001154367.1
    • decapping 5 (DCP5); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: negative regulation of translation, deadenylation-independent decapping of nuclear-transcribed mRNA, cytoplasmic mRNA processing body assembly; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DFDF motif (InterPro:IPR019050), FFD/TFG box motif (InterPro:IPR019053); BEST Arabidopsis thaliana protein match is: decapping 5-like (TAIR:AT5G45330.1); Has 14874 Blast hits to 10327 proteins in 603 species: Archae - 12; Bacteria - 902; Metazoa - 6418; Fungi - 2978; Plants - 1226; Viruses - 261; Other Eukaryotes - 3077 (source: NCBI BLink).
    NP_564239.1
    • decapping 5 (DCP5); CONTAINS InterPro DOMAIN/s: DFDF motif (InterPro:IPR019050), FFD/TFG box motif (InterPro:IPR019053); BEST Arabidopsis thaliana protein match is: decapping 5-like (TAIR:AT5G45330.1); Has 46741 Blast hits to 20189 proteins in 1086 species: Archae - 36; Bacteria - 10029; Metazoa - 17132; Fungi - 5632; Plants - 6968; Viruses - 649; Other Eukaryotes - 6295 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9024341..9027955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102376.4 → NP_564239.1  decapping 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHI7, F4IE33, Q8RWC4, Q9ASU0, Q9C604, Q9C658
      UniProtKB/TrEMBL
      A0A178WFG5, A0A5S9VY65
      Conserved Domains (3) summary
      pfam07462
      Location:323 → 399
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
      pfam09532
      Location:460 → 553
      FDF; FDF domain
      pfam12701
      Location:16 → 88
      LSM14; Scd6-like Sm domain

    2. NM_001160895.1 → NP_001154367.1  decapping 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WFG5, A0A5S9VY65
      Conserved Domains (3) summary
      pfam07462
      Location:323 → 399
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
      pfam09532
      Location:454 → 547
      FDF; FDF domain
      pfam12701
      Location:16 → 88
      LSM14; Scd6-like Sm domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C658.1

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