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    CRC Plant-specific transcription factor YABBY family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843249, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRC
    Official Full Name
    Plant-specific transcription factor YABBY family protein
    Primary source
    TAIR:AT1G69180
    Locus tag
    AT1G69180
    See related
    Araport:AT1G69180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CRABS CLAW; F4N2.14; F4N2_14; TRANSCRIPTION FACTOR CRC
    Summary
    Putative transcription factor with zinc finger and helix-loop-helix domains, the later similar to HMG boxes. Involved in specifying abaxial cell fate in the carpel. Four putative LFY binding sites (CCANTG) and two potential binding sites for MADS box proteins known as CArG boxes (CC(A/T)6GG) were found in the region spanning 3.8 Kb upstream of the CRC coding region.
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    Genomic context

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    See CRC in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (26007350..26009141, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene suppressor Neighboring gene Squamosa promoter-binding protein-like (SBP domain) transcription factor family protein Neighboring gene Dihydropterin pyrophosphokinase / Dihydropteroate synthase Neighboring gene fructokinase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription Factor Action Orchestrates the Complex Expression Pattern of CRABS CLAW in Arabidopsis. Gross T, et al. Genes (Basel), 2021 Oct 21. PMID 34828269, Free PMC Article
    2. Functional conservation between CRABS CLAW orthologues from widely diverged angiosperms. Fourquin C, et al. Ann Bot, 2007 Sep. PMID 17650514, Free PMC Article
    3. Activation of CRABS CLAW in the Nectaries and Carpels of Arabidopsis. Lee JY, et al. Plant Cell, 2005 Jan. PMID 15598802, Free PMC Article
    4. CRABS CLAW, a gene that regulates carpel and nectary development in Arabidopsis, encodes a novel protein with zinc finger and helix-loop-helix domains. Bowman JL, et al. Development, 1999 Jun. PMID 10225998
    5. Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis. Han X, et al. J Integr Plant Biol, 2012 Jul. PMID 22676405

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription Factor Action Orchestrates the Complex Expression Pattern of CRABS CLAW in Arabidopsis.
      Title: Transcription Factor Action Orchestrates the Complex Expression Pattern of CRABS CLAW in Arabidopsis.
    2. The feed-forward YUC4 activation by AG and CRC directs a precise change in chromatin state for the shift from floral stem cell maintenance to gynoecium formation.
      Title: Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy.
    3. Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis.
      Title: Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis.
    4. The data support a hypothesized ancestral role for CRC in carpel development and suggest that novel roles for CRC orthologues in monocots and in core eudicots resulted principally from molecular changes other than those affecting their coding sequences.
      Title: Functional conservation between CRABS CLAW orthologues from widely diverged angiosperms.
    5. MADS box proteins may provide general floral factors that must work in conjunction with specific factors in the activation of CRC in the nectaries and carpels.
      Title: Activation of CRABS CLAW in the Nectaries and Carpels of Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105585.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carpel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floral meristem determinacy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within nectary development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within polarity specification of adaxial/abaxial axis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within style development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Plant-specific transcription factor YABBY family protein
    NP_177078.1
    • CRABS CLAW (CRC); CONTAINS InterPro DOMAIN/s: High mobility group, superfamily (InterPro:IPR009071), YABBY protein (InterPro:IPR006780); BEST Arabidopsis thaliana protein match is: Plant-specific transcription factor YABBY family protein (TAIR:AT1G08465.1); Has 451 Blast hits to 449 proteins in 129 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 8; Plants - 437; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26007350..26009141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105585.3 → NP_177078.1  Plant-specific transcription factor YABBY family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L925, Q9LQA3, Q9XHD1
      UniProtKB/TrEMBL
      A0A178WAK3, A0A5S9WSR6, Q1PFF1
      Conserved Domains (1) summary
      pfam04690
      Location:18 → 156
      YABBY; YABBY protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L925.2

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