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    ERD2 ER lumen protein retaining receptor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839807, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERD2
    Official Full Name
    ER lumen protein retaining receptor family protein
    Primary source
    TAIR:AT1G29330
    Locus tag
    AT1G29330
    See related
    Araport:AT1G29330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AERD2; ARABIDOPSIS ENDOPLASMIC RETICULUM RETENTION DEFECTIVE 2; ARABIDOPSIS THALIANA ENDOPLASMIC RETICULUM RETENTION DEFECTIVE 2; ATERD2; ENDOPLASMIC RETICULUM RETENTION DEFECTIVE 2; F28N24.1
    Summary
    Encodes a protein similar in sequence to animal and yeast endoplasmic reticulum retention signal receptor. This protein can functionally complement the yeast homologue. Transcript is detected in flower buds, stems, root, and leaves.
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    Genomic context

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    See ERD2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (10258248..10261232, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene intracellular protein transporter, putative (DUF641) Neighboring gene SecY protein transport family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene plant U-box 17 Neighboring gene RNA polymerase II degradation factor-like protein (DUF1296)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Arabidopsis p24 function affects ERD2 trafficking and Golgi structure, and activates the unfolded protein response. Pastor-Cantizano N, et al. J Cell Sci, 2018 Jan 29. PMID 28871045
    2. The Arabidopsis endoplasmic reticulum retention receptor functions in yeast. Lee HI, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248265, Free PMC Article
    3. A dominant negative mutant of sar1 GTPase inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus in tobacco and Arabidopsis cultured cells. Takeuchi M, et al. Plant J, 2000 Aug. PMID 10972878
    4. Arabidopsis p24δ5 and p24δ9 facilitate Coat Protein I-dependent transport of the K/HDEL receptor ERD2 from the Golgi to the endoplasmic reticulum. Montesinos JC, et al. Plant J, 2014 Dec. PMID 25312353
    5. Sec22 and Memb11 are v-SNAREs of the anterograde endoplasmic reticulum-Golgi pathway in tobacco leaf epidermal cells. Chatre L, et al. Plant Physiol, 2005 Nov. PMID 16244155, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p24 proteins play a role in the organization of the compartments of the early secretory pathway in Arabidopsis Loss of p24delta-1 proteins also induced the accumulation of the K/HDEL receptor ERD2a at the Golgi.
      Title: Loss of Arabidopsis p24 function affects ERD2 trafficking and Golgi structure, and activates the unfolded protein response.
    2. Arabidopsis p24delta5/delta9 and HDEL ligands shift the steady-state distribution of the K/HDEL receptor ERD2 from the Golgi to the endoplasmic reticulum (ER).
      Title: Arabidopsis p24δ5 and p24δ9 facilitate Coat Protein I-dependent transport of the K/HDEL receptor ERD2 from the Golgi to the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332846.1
    NM_102673.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ER retention sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables KDEL sequence binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein retention in ER lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein retention in ER lumen IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ER lumen protein retaining receptor family protein
    NP_564326.1
    • ENDOPLASMIC RETICULUM RETENTION DEFECTIVE 2 (ERD2); CONTAINS InterPro DOMAIN/s: ER lumen protein retaining receptor (InterPro:IPR000133); BEST Arabidopsis thaliana protein match is: endoplasmic reticulum retention defective 2B (TAIR:AT3G25040.1); Has 909 Blast hits to 907 proteins in 229 species: Archae - 0; Bacteria - 0; Metazoa - 321; Fungi - 187; Plants - 229; Viruses - 0; Other Eukaryotes - 172 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10258248..10261232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102673.6 → NP_564326.1  ER lumen protein retaining receptor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564326.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35402
      UniProtKB/TrEMBL
      A0A5S9WAG3, A0A654EDU3, A0A7G2DTY0
      Conserved Domains (1) summary
      pfam00810
      Location:28 → 171
      ER_lumen_recept; ER lumen protein retaining receptor

    2. NM_001332846.1 → NP_001321392.1  ER lumen protein retaining receptor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WIU4, A0A1P8AQU1, A0A384KNI4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35402.1

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