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    WRR4 Disease resistance protein (TIR-NBS-LRR class) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842104, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WRR4
    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class)
    Primary source
    TAIR:AT1G56510
    Locus tag
    AT1G56510
    See related
    Araport:AT1G56510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACTIVATED DISEASE RESISTANCE 2; ADR2; F13N6.5; F13N6_5; WHITE RUST RESISTANCE 4
    Summary
    TIR-NB-LRR protein that confers resistance to four races of Albugo candida.
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    Genomic context

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    See WRR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (21167565..21173632)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene haloacid dehalogenase-like hydrolase family protein Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene hydroxyproline-rich glycoprotein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities. Castel B, et al. Plant J, 2021 Sep. PMID 34181787
    2. Arabidopsis thaliana natural variation reveals connections between UV radiation stress and plant pathogen-like defense responses. Piofczyk T, et al. Plant Physiol Biochem, 2015 Aug. PMID 25656510
    3. WRR4, a broad-spectrum TIR-NB-LRR gene from Arabidopsis thaliana that confers white rust resistance in transgenic oilseed Brassica crops. Borhan MH, et al. Mol Plant Pathol, 2010 Mar. PMID 20447277, Free PMC Article
    4. Activation tagging of ADR2 conveys a spreading lesion phenotype and resistance to biotrophic pathogens. Aboul-Soud MAM, et al. New Phytol, 2009. PMID 19549129
    5. WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis thaliana to four physiological races of Albugo candida. Borhan MH, et al. Mol Plant Microbe Interact, 2008 Jun. PMID 18624640

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities.
      Title: Evolutionary trade-offs at the Arabidopsis WRR4A resistance locus underpin alternate Albugo candida race recognition specificities.
    2. adr2-mediated resistance operates through an Enhanced Disease Susceptibility (EDS) and SA-dependent defence signalling network which functions independently from COI1 or ETR1. [activated disease resistance 2] [ADR2]
      Title: Activation tagging of ADR2 conveys a spreading lesion phenotype and resistance to biotrophic pathogens.
    3. WRR4 could potentially provide a novel source of white rust resistance in oilseed and vegetable brassica crops.
      Title: WRR4, a broad-spectrum TIR-NB-LRR gene from Arabidopsis thaliana that confers white rust resistance in transgenic oilseed Brassica crops.
    4. WRR4 (At1g56510 )encodes a cytoplasmic toll-interleukin receptor-like nucleotide-binding leucine-rich repeat receptor-like protein that confers a dominant, broad-spectrum white rust resistance(WRR
      Title: WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis thaliana to four physiological races of Albugo candida.
    Submit: New GeneRIF Correction

    General gene information

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    NM_104527.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class)
    NP_176043.1
    • WHITE RUST RESISTANCE 4 (WRR4); FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: defense response to fungus, incompatible interaction, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT1G56540.1); Has 19205 Blast hits to 15135 proteins in 571 species: Archae - 14; Bacteria - 975; Metazoa - 1259; Fungi - 71; Plants - 16420; Viruses - 8; Other Eukaryotes - 458 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21167565..21173632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104527.4 → NP_176043.1  Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C7X0
      UniProtKB/TrEMBL
      A0A5S9WQ84, A0A654EP54
      Conserved Domains (6) summary
      PLN03210
      Location:1 → 997
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:603 → 621
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:626 → 648
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam01582
      Location:13 → 176
      TIR; TIR domain
      pfam07725
      Location:602 → 621
      LRR_3; Leucine Rich Repeat
      pfam13191
      Location:187 → 310
      AAA_16; AAA ATPase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C7X0.1

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