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    FUG1 Translation initiation factor 2, small GTP-binding protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FUG1
    Official Full Name
    Translation initiation factor 2, small GTP-binding protein
    Primary source
    TAIR:AT1G17220
    Locus tag
    AT1G17220
    See related
    Araport:AT1G17220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F20D23.8; F20D23_8; fu-gaeri1
    Summary
    Encodes a chloroplast localized protein with similarity to translation initiation factor 2. Can complement loss of INFB in E.coli suggesting FUG1 does function as a translation initiation factor in vivo. Identified as a suppressor of the leaf variegation mutant var2-6. Suppression is only seen in hypomorphs as complete loss of function alleles are embryo lethal.
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    Genomic context

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    See FUG1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (5885007..5890500)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase tau 26 Neighboring gene Uncharacterized protein family (UPF0497) Neighboring gene IAP-like protein 1 Neighboring gene ncRNA Neighboring gene Leucine-rich receptor-like protein kinase family protein Neighboring gene ROTUNDIFOLIA like 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relationship of GUN1 to FUG1 in chloroplast protein homeostasis. Marino G, et al. Plant J, 2019 Aug. PMID 31002470
    2. SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana. Sureshkumar S, et al. Nat Plants, 2024 May. PMID 38641663
    3. The balance between protein synthesis and degradation in chloroplasts determines leaf variegation in Arabidopsis yellow variegated mutants. Miura E, et al. Plant Cell, 2007 Apr. PMID 17416734, Free PMC Article
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.
      Title: SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.
    2. Data show that Arabidopsis proteins GUN1 and FUG1 are required for effective cold acclimation.
      Title: Relationship of GUN1 to FUG1 in chloroplast protein homeostasis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_101583.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Translation initiation factor 2, small GTP-binding protein
    NP_173165.1
    • fu-gaeri1 (FUG1); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Translation initiation factor IF-2, N-terminal (InterPro:IPR006847), Small GTP-binding protein (InterPro:IPR005225), Translation elongation factor EFTu/EF1A, domain 2 (InterPro:IPR004161), Translation initiation factor 2 related (InterPro:IPR015760), Initiation factor 2 (InterPro:IPR000178), Protein synthesis factor, GTP-binding (InterPro:IPR000795), Translation elongation/initiation factor/Ribosomal, beta-barrel (InterPro:IPR009000); BEST Arabidopsis thaliana protein match is: Translation initiation factor 2, small GTP-binding protein (TAIR:AT4G11160.1); Has 64472 Blast hits to 64325 proteins in 4737 species: Archae - 1215; Bacteria - 42273; Metazoa - 2198; Fungi - 2344; Plants - 1110; Viruses - 4; Other Eukaryotes - 15328 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5885007..5890500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101583.4 → NP_173165.1  Translation initiation factor 2, small GTP-binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DI35, Q9ASQ3, Q9SHI1
      UniProtKB/TrEMBL
      A0A178WBD9, A0A5S9UUG7, A0A654EAL5
      Conserved Domains (1) summary
      PRK05306
      Location:278 → 1009
      infB; translation initiation factor IF-2; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SHI1.2

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