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    CPN60B chaperonin 60 beta [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841996, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPN60B
    Official Full Name
    chaperonin 60 beta
    Primary source
    TAIR:AT1G55490
    Locus tag
    AT1G55490
    See related
    Araport:AT1G55490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    chaperonin 60 beta; chaperonin-60beta1; CPN60BETA; Cpn60beta1; LEN1; LESION INITIATION 1; T5A14.11; T5A14_11
    Summary
    encodes the beta subunit of the chloroplast chaperonin 60, a homologue of bacterial GroEL. Mutants in this gene develops lesions on its leaves, expresses systemic acquired resistance (SAR) and develops accelerated cell death to heat shock stress. The protein has molecular chaperone activity for suppressing protein aggregation in vitro.
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    Genomic context

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    See CPN60B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (20715563..20719261, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene protein containing PDZ domain, a K-box domain, and a TPR region Neighboring gene evolutionarily conserved C-terminal region 4 Neighboring gene branched-chain alpha-keto acid decarboxylase E1 beta subunit Neighboring gene TATA binding protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of genes encoding chaperonin 60 beta from Arabidopsis thaliana. Zabaleta E, et al. Gene, 1992 Feb 15. PMID 1347275
    2. Deletion of a chaperonin 60 beta gene leads to cell death in the Arabidopsis lesion initiation 1 mutant. Ishikawa A, et al. Plant Cell Physiol, 2003 Mar. PMID 12668771
    3. Association of Rubisco activase with chaperonin-60beta: a possible mechanism for protecting photosynthesis during heat stress. Salvucci ME. J Exp Bot, 2008. PMID 18353762
    4. Plastid chaperonin proteins Cpn60 alpha and Cpn60 beta are required for plastid division in Arabidopsis thaliana. Suzuki K, et al. BMC Plant Biol, 2009 Apr 6. PMID 19344532, Free PMC Article
    5. PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1. Mao J, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775508, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Moderate reduction of Cpn60-beta protein levels impaired plastid division while severe loss abolished greening of plastids. [Cpn60-beta]
      Title: Plastid chaperonin proteins Cpn60 alpha and Cpn60 beta are required for plastid division in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333710.1
    NM_001333711.1
    NM_001333712.1
    NM_104424.2
    NM_179480.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein folding TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chaperonin 60 beta
    NP_175945.1
    • chaperonin 60 beta (CPN60B); FUNCTIONS IN: protein binding; INVOLVED IN: protein folding, systemic acquired resistance, cell death, response to cold, chaperone mediated protein folding requiring cofactor; LOCATED IN: in 8 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Chaperonin Cpn60, conserved site (InterPro:IPR018370), Chaperonin Cpn60 (InterPro:IPR001844); BEST Arabidopsis thaliana protein match is: TCP-1/cpn60 chaperonin family protein (TAIR:AT3G13470.1); Has 34209 Blast hits to 34175 proteins in 8723 species: Archae - 804; Bacteria - 21846; Metazoa - 1741; Fungi - 1612; Plants - 841; Viruses - 2; Other Eukaryotes - 7363 (source: NCBI BLink).
    NP_849811.1
    • chaperonin 60 beta (CPN60B); FUNCTIONS IN: protein binding; INVOLVED IN: protein folding, systemic acquired resistance, cell death, response to cold, chaperone mediated protein folding requiring cofactor; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Chaperonin Cpn60, conserved site (InterPro:IPR018370), Chaperonin Cpn60 (InterPro:IPR001844); BEST Arabidopsis thaliana protein match is: TCP-1/cpn60 chaperonin family protein (TAIR:AT3G13470.1); Has 34209 Blast hits to 34175 proteins in 8723 species: Archae - 804; Bacteria - 21846; Metazoa - 1741; Fungi - 1612; Plants - 841; Viruses - 2; Other Eukaryotes - 7363 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20715563..20719261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179480.3 → NP_849811.1  chaperonin 60 beta [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS9, B9DHQ8, P21240, Q9SAV2
      UniProtKB/TrEMBL
      A0A178VIX7, A0A178W724, A0A5S9WM41, A0A5S9XBS6
      Conserved Domains (1) summary
      PLN03167
      Location:1 → 600
      PLN03167; Chaperonin-60 beta subunit; Provisional

    2. NM_001333712.1 → NP_001320637.1  chaperonin 60 beta [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS9, B9DHQ8, P21240, Q9SAV2
      UniProtKB/TrEMBL
      A0A178VIX7, A0A178W724, A0A5S9WM41, A0A5S9XBS6
      Conserved Domains (1) summary
      PLN03167
      Location:1 → 600
      PLN03167; Chaperonin-60 beta subunit; Provisional

    3. NM_001333711.1 → NP_001320638.1  chaperonin 60 beta [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS9, B9DHQ8, P21240, Q9SAV2
      UniProtKB/TrEMBL
      A0A178VIX7, A0A178W724, A0A5S9WM41, A0A5S9XBS6
      Conserved Domains (1) summary
      PLN03167
      Location:1 → 600
      PLN03167; Chaperonin-60 beta subunit; Provisional

    4. NM_001333710.1 → NP_001320639.1  chaperonin 60 beta [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS9, B9DHQ8, P21240, Q9SAV2
      UniProtKB/TrEMBL
      A0A178VIX7, A0A178W724, A0A5S9WM41, A0A5S9XBS6
      Conserved Domains (1) summary
      PLN03167
      Location:1 → 600
      PLN03167; Chaperonin-60 beta subunit; Provisional

    5. NM_104424.2 → NP_175945.1  chaperonin 60 beta [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFS9, B9DHQ8, P21240, Q9SAV2
      UniProtKB/TrEMBL
      A0A178VIX7, A0A178W724, A0A5S9WM41, A0A5S9XBS6
      Conserved Domains (1) summary
      PLN03167
      Location:1 → 600
      PLN03167; Chaperonin-60 beta subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21240.3

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