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    MKK9 MAP kinase kinase 9 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843685, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MKK9
    Official Full Name
    MAP kinase kinase 9
    Primary source
    TAIR:AT1G73500
    Locus tag
    AT1G73500
    See related
    Araport:AT1G73500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMKK9; MAP kinase kinase 9; T9L24.32; T9L24_32
    Summary
    member of MAP Kinase Kinase family. Autophosphorylates and also phosphorylates MPK3 and MPK6. Independently involved in ethylene and calmalexin biosynthesis. Induces transcription of ACS2, ACS6, ERF1, ERF2, ERF5, ERF6, CYP79B2, CYP79B3, CYP71A13 and PAD3.
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    Genomic context

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    See MKK9 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (27639091..27640643, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis. Luo J, et al. Biochem Biophys Res Commun, 2017 Jun 3. PMID 28435067
    2. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Yoo SD, et al. Nature, 2008 Feb 14. PMID 18273012, Free PMC Article
    3. Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress. Shen L, et al. Plant Sci, 2019 Oct. PMID 31481213
    4. An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence. Zhou C, et al. Plant Physiol, 2009 May. PMID 19251906, Free PMC Article
    5. Expression analysis of MAP2K9 and MAPK6 during pathogenesis of Alternaria blight in Arabidopsis thaliana ecotype Columbia. Kannan P, et al. Mol Biol Rep, 2012 Apr. PMID 21947882

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that phosphatidic acid (PA) binds to MKK7 and MKK9, increases their kinase activity and plasma membrane localization during Arabidopsis response to salt stress.
      Title: Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress.
    2. The results suggest that MKK9 plays a role in plant adaptation to low N stress by modulating both anthocyanin accumulation and N status.
      Title: The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis.
    3. MKK4, MKK5, MKK7, and MKK9, are responsible for the activation of MPK3 and MPK6 by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK signaling through MKK4/5/7/9-MPK3/6 cascades.
      Title: Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants.
    4. These results suggest that the MKK9-MPK3/MPK6 cascade is part of the phosphate signaling pathway in plants.
      Title: Activation of MKK9-MPK3/MPK6 enhances phosphate acquisition in Arabidopsis thaliana.
    5. The studies have suggested that MAPK module consisting of MAP2K9/MAPK6 could be possible target influenced by pathogen of Alternaria blight. [MAP2K9]
      Title: Expression analysis of MAP2K9 and MAPK6 during pathogenesis of Alternaria blight in Arabidopsis thaliana ecotype Columbia.
    6. MKK9 has a role in the timing of leaf senescence.
      Title: An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence.
    7. the MKK9-MPK3/MPK6 cascade participates in the regulation of the biosynthesis of ethylene and camalexin and may be an important axis in the stress responses of Arabidopsis.
      Title: Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106009.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within camalexin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within ethylene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen-pistil interaction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase kinase 9
    NP_177492.1
    • MAP kinase kinase 9 (MKK9); FUNCTIONS IN: protein kinase activator activity, MAP kinase kinase activity, kinase activity; INVOLVED IN: in 7 processes; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 7 (TAIR:AT1G18350.1); Has 126854 Blast hits to 125581 proteins in 4823 species: Archae - 172; Bacteria - 14892; Metazoa - 47012; Fungi - 12114; Plants - 31822; Viruses - 500; Other Eukaryotes - 20342 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27639091..27640643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106009.3 → NP_177492.1  MAP kinase kinase 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FX43
      UniProtKB/TrEMBL
      A0A178W135, A0A5S9WU12, A0A7G2E8L9
      Conserved Domains (1) summary
      cd06623
      Location:46 → 308
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FX43.1

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