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    LINC1 little nuclei1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843043, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LINC1
    Official Full Name
    little nuclei1
    Primary source
    TAIR:AT1G67230
    Locus tag
    AT1G67230
    See related
    Araport:AT1G67230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    (Japanese for nucleus) 2; AtLINC1; CROWDED NUCLEI 1; CRWN1; F1N21.5; KAKU2; LITTLE NUCLEI1
    Summary
    Encodes a nuclear coiled-coil protein related to the carrot peripheral nuclear protein NMCP1 that is involved in the determination of plant nuclear structure.
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    Genomic context

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    See LINC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (25151211..25156389, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene histone acetyltransferase of the CBP family 2 Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant lamin-like proteins mediate chromatin tethering at the nuclear periphery. Hu B, et al. Genome Biol, 2019 Apr 30. PMID 31039799, Free PMC Article
    2. Subnuclear gene positioning through lamina association affects copper tolerance. Sakamoto Y, et al. Nat Commun, 2020 Nov 20. PMID 33219233, Free PMC Article
    3. The Chromatin-Associated Protein PWO1 Interacts with Plant Nuclear Lamin-like Components to Regulate Nuclear Size. Mikulski P, et al. Plant Cell, 2019 May. PMID 30914470, Free PMC Article
    4. LITTLE NUCLEI genes affecting nuclear morphology in Arabidopsis thaliana. Dittmer TA, et al. Plant Cell, 2007 Sep. PMID 17873096, Free PMC Article
    5. Loss of CRWN Nuclear Proteins Induces Cell Death and Salicylic Acid Defense Signaling. Choi J, et al. Plant Physiol, 2019 Apr. PMID 30696746, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subnuclear gene positioning through lamina association affects copper tolerance.
      Title: Subnuclear gene positioning through lamina association affects copper tolerance.
    2. PWO1 and CRWN1 proteins associate physically with each other, act in the same pathway to maintain nuclear morphology, and control expression of a similar set of target genes.
      Title: The Chromatin-Associated Protein PWO1 Interacts with Plant Nuclear Lamin-like Components to Regulate Nuclear Size.
    3. key component of the lamina-chromatin network in plants, functionally equivalent to animal lamins, playing critical roles in modulating patterns of chromatin positioning at the nuclear periphery
      Title: Plant lamin-like proteins mediate chromatin tethering at the nuclear periphery.
    4. mutations trigger widespread changes in transcript levels and whole-plant phenotypes
      Title: Loss of CRWN Nuclear Proteins Induces Cell Death and Salicylic Acid Defense Signaling.
    5. role in diminishing ROS accumulation and protecting genomic DNA against excessive oxidative damage caused by methyl methanesulfonate
      Title: Roles of CRWN-family proteins in protecting genomic DNA against oxidative damage.
    6. CRWN1 represses PR1 transcription by interacting with NTL9
      Title: Lamin-like Proteins Negatively Regulate Plant Immunity through NAC WITH TRANSMEMBRANE MOTIF1-LIKE9 and NONEXPRESSOR OF PR GENES1 in Arabidopsis thaliana.
    7. These results suggested important roles of CRWNs in ABI5 nuclear body organization and ABI5 protein degradation during seed germination.
      Title: The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein.
    8. Roles of the respective WIT and SUN paralogs have diverged in trichomes and root hairs, and that the SUN-WIP-WIT2-myosin XI-i complex and CRWN1 independently determine elongated nuclear shape. This supports a model of nuclei being shaped both by cytoplasmic forces transferred to the NE and by nucleoplasmic filaments formed under the NE. [CRWN1]
      Title: Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
    9. associations between AtLINC1 and plant SUN proteins
      Title: Evidence for LINC1-SUN associations at the plant nuclear periphery.
    10. These results indicate that the LINC coiled-coil proteins are important determinants of plant nuclear structure. [LINC1]
      Title: LITTLE NUCLEI genes affecting nuclear morphology in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105392.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleus size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    little nuclei1
    NP_176892.1
    • LITTLE NUCLEI1 (LINC1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: nucleus organization; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: nuclear matrix constituent protein-related (TAIR:AT1G13220.2); Has 314297 Blast hits to 138342 proteins in 3965 species: Archae - 3454; Bacteria - 70538; Metazoa - 123746; Fungi - 25476; Plants - 17143; Viruses - 1173; Other Eukaryotes - 72767 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25151211..25156389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105392.5 → NP_176892.1  little nuclei1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HRT5, Q0WKV7, Q8GZ88, Q9FYH0
      UniProtKB/TrEMBL
      A0A5S9WSY2, A0A654ERW1
      Conserved Domains (1) summary
      COG1196
      Location:53 → 741
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HRT5.1

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