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    ALAAT2 alanine aminotransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843565, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALAAT2
    Official Full Name
    alanine aminotransferase 2
    Primary source
    TAIR:AT1G72330
    Locus tag
    AT1G72330
    See related
    Araport:AT1G72330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alanine aminotransferase 2; ALANINE AMINOTRANSFERASE 2; T10D10.20; T10D10_20
    Summary
    Encodes for alanine aminotransferase ALAAT2.
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    Genomic context

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    See ALAAT2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (27233418..27236822)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene pumilio 23 Neighboring gene NagB/RpiA/CoA transferase-like superfamily protein Neighboring gene MADS-box transcription factor family protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene 40s ribosomal protein SA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two alanine aminotranferases link mitochondrial glycolate oxidation to the major photorespiratory pathway in Arabidopsis and rice. Niessen M, et al. J Exp Bot, 2012 Apr. PMID 22268146, Free PMC Article
    2. Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana. Miyashita Y, et al. Plant J, 2007 Mar. PMID 17319845
    3. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALAAT1 and ALAAT2 link mitochondrial glycolate oxidation to the major photorespiratory pathway.
      Title: Two alanine aminotranferases link mitochondrial glycolate oxidation to the major photorespiratory pathway in Arabidopsis and rice.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084342.1
    NM_001198451.1
    NM_105892.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables copper ion binding HDA PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    alanine aminotransferase 2
    NP_001077811.1
    • alanine aminotransferase 2 (ALAAT2); FUNCTIONS IN: copper ion binding, L-alanine:2-oxoglutarate aminotransferase activity, ATP binding; INVOLVED IN: biosynthetic process; LOCATED IN: mitochondrion; CONTAINS InterPro DOMAIN/s: Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: alanine aminotransferas (TAIR:AT1G17290.1); Has 25714 Blast hits to 25709 proteins in 2861 species: Archae - 758; Bacteria - 18437; Metazoa - 630; Fungi - 646; Plants - 1232; Viruses - 0; Other Eukaryotes - 4011 (source: NCBI BLink).
    NP_001185380.1
    • alanine aminotransferase 2 (ALAAT2); FUNCTIONS IN: copper ion binding, L-alanine:2-oxoglutarate aminotransferase activity; INVOLVED IN: biosynthetic process; CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: alanine aminotransferas (TAIR:AT1G17290.1).
    NP_565040.2
    • alanine aminotransferase 2 (ALAAT2); FUNCTIONS IN: copper ion binding, L-alanine:2-oxoglutarate aminotransferase activity, ATP binding; INVOLVED IN: glycolysis, biosynthetic process, L-alanine biosynthetic process from pyruvate, L-alanine catabolic process, by transamination; LOCATED IN: mitochondrion; CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: alanine aminotransferas (TAIR:AT1G17290.1); Has 29092 Blast hits to 29084 proteins in 2917 species: Archae - 792; Bacteria - 20006; Metazoa - 643; Fungi - 676; Plants - 1274; Viruses - 0; Other Eukaryotes - 5701 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27233418..27236822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105892.5 → NP_565040.2  alanine aminotransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565040.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IDA2, F4IDA4, Q94C83, Q9C7S4, Q9LDV4
      UniProtKB/TrEMBL
      A0A178WAU5, A0A5S9WT98
      Conserved Domains (2) summary
      cd00609
      Location:155 → 529
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PLN02231
      Location:1 → 540
      PLN02231; alanine transaminase

    2. NM_001198451.1 → NP_001185380.1  alanine aminotransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WAU5, A0A5S9WT98
      Conserved Domains (2) summary
      cd00609
      Location:155 → 542
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PLN02231
      Location:1 → 553
      PLN02231; alanine transaminase

    3. NM_001084342.1 → NP_001077811.1  alanine aminotransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LDV4
      Conserved Domains (1) summary
      cd00609
      Location:155 → 413
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LDV4.1

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