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    OPR2 12-oxophytodienoate reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844002, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OPR2
    Official Full Name
    12-oxophytodienoate reductase 2
    Primary source
    TAIR:AT1G76690
    Locus tag
    AT1G76690
    See related
    Araport:AT1G76690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    12-oxophytodienoate reductase 2; 12-OXOPHYTODIENOATE REDUCTASE 2; ARABIDOPSIS 12-OXOPHYTODIENOATE REDUCTASE 2; ATOPR2; F28O16.6; F28O16_6
    Summary
    Encodes one of the closely related 12-oxophytodienoic acid reductases. This enzyme is not expected to participate in jasmonic acid biosynthesis because during in vitro assays, it shows very little activity with the naturally occurring OPDA isomer. Shows activity towards 2,4,6-trinitrotoluene. Expressed predominately in root. Predicted to be a cytosolic protein.
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    Genomic context

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    See OPR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (28778622..28780483)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Nucleotide-sugar transporter family protein Neighboring gene miscRNA Neighboring gene 12-oxophytodienoate reductase 1 Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An OPR3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis. Chini A, et al. Nat Chem Biol, 2018 Feb. PMID 29291349
    2. SH2 domains in plants imply new signalling scenarios. Williams JG, et al. Trends Plant Sci, 2004 Apr. PMID 15063865
    3. 12-Oxophytodienoate reductase 3 (OPR3) is the isoenzyme involved in jasmonate biosynthesis. Schaller F, et al. Planta, 2000 May. PMID 10872231
    4. Structure and regulation of OPR1 and OPR2, two closely related genes encoding 12-oxophytodienoic acid-10,11-reductases from Arabidopsis thaliana. Biesgen C, et al. Planta, 1999 Apr. PMID 10333582
    5. The role of oxophytodienoate reductases in the detoxification of the explosive 2,4,6-trinitrotoluene by Arabidopsis. Beynon ER, et al. Plant Physiol, 2009 Sep. PMID 19605548, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_106319.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 12-oxophytodienoate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 12-oxophytodienoate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in jasmonic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in jasmonic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    12-oxophytodienoate reductase 2
    NP_177795.1
    • 12-oxophytodienoate reductase 2 (OPR2); CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), NADH:flavin oxidoreductase/NADH oxidase, N-terminal (InterPro:IPR001155); BEST Arabidopsis thaliana protein match is: 12-oxophytodienoate reductase 1 (TAIR:AT1G76680.1); Has 13197 Blast hits to 13176 proteins in 2056 species: Archae - 127; Bacteria - 9811; Metazoa - 29; Fungi - 865; Plants - 452; Viruses - 0; Other Eukaryotes - 1913 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28778622..28780483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106319.5 → NP_177795.1  12-oxophytodienoate reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177795.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LYX5, Q8GYB8, Q9ZR80
      UniProtKB/TrEMBL
      A0A178W9S3, A0A5S9WV15
      Conserved Domains (1) summary
      cd02933
      Location:13 → 352
      OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GYB8.2

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