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    SPL4 squamosa promoter binding protein-like 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841749, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPL4
    Official Full Name
    squamosa promoter binding protein-like 4
    Primary source
    TAIR:AT1G53160
    Locus tag
    AT1G53160
    See related
    Araport:AT1G53160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F8L10.12; F8L10_12; FLORAL TRANSITION AT THE MERISTEM6; FTM6; squamosa promoter binding protein-like 4
    Summary
    Encodes a member of the SPL (squamosa-promoter binding protein-like)gene family, a novel gene family encoding DNA binding proteins and putative transcription factors. Contains the SBP-box, which encodes the SBP-domain, required and sufficient for interaction with DNA. It is involved in regulation of flowering and vegetative phase change. Its temporal expression is regulated by the microRNA miR156. The target site for the microRNA is in the 3'UTR.
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    Genomic context

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    See SPL4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (19806263..19807705)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dynamin related protein 5A Neighboring gene ncRNA Neighboring gene membrane-associated kinase regulator Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPL3/4/5 Integrate Developmental Aging and Photoperiodic Signals into the FT-FD Module in Arabidopsis Flowering. Jung JH, et al. Mol Plant, 2016 Dec 5. PMID 27815142
    2. miR172 signals are incorporated into the miR156 signaling pathway at the SPL3/4/5 genes in Arabidopsis developmental transitions. Jung JH, et al. Plant Mol Biol, 2011 May. PMID 21373962
    3. Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3. Wu G, et al. Development, 2006 Sep. PMID 16914499, Free PMC Article
    4. Interactome analysis reveals versatile functions of Arabidopsis COLD SHOCK DOMAIN PROTEIN 3 in RNA processing within the nucleus and cytoplasm. Kim MH, et al. Cell Stress Chaperones, 2013 Jul. PMID 23334891, Free PMC Article
    5. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPL3/4/5 Integrate Developmental Aging and Photoperiodic Signals into the FT-FD Module in Arabidopsis Flowering.
      Title: SPL3/4/5 Integrate Developmental Aging and Photoperiodic Signals into the FT-FD Module in Arabidopsis Flowering.
    2. Data indicate that although miR172 and miR156 play distinct roles in the timing of developmental phase transitions, there is a signaling crosstalk mediated by the SPL3/4/5 genes.
      Title: miR172 signals are incorporated into the miR156 signaling pathway at the SPL3/4/5 genes in Arabidopsis developmental transitions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333580.1
    NM_104194.4
    NM_202285.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flower development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of vegetative phase change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    squamosa promoter binding protein-like 4
    NP_175723.1
    • squamosa promoter binding protein-like 4 (SPL4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of vegetative phase change, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Squamosa promoter-binding protein (InterPro:IPR017238), Transcription factor, SBP-box (InterPro:IPR004333); BEST Arabidopsis thaliana protein match is: squamosa promoter binding protein-like 5 (TAIR:AT3G15270.1); Has 846 Blast hits to 845 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 846; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
    NP_974014.1
    • squamosa promoter binding protein-like 4 (SPL4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of vegetative phase change, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Squamosa promoter-binding protein (InterPro:IPR017238), Transcription factor, SBP-box (InterPro:IPR004333); BEST Arabidopsis thaliana protein match is: squamosa promoter binding protein-like 5 (TAIR:AT3G15270.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19806263..19807705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104194.4 → NP_175723.1  squamosa promoter binding protein-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7A9, Q9SMX8
      UniProtKB/TrEMBL
      A0A178WEY0, A0A5S9WRD5
      Conserved Domains (1) summary
      pfam03110
      Location:54 → 128
      SBP; SBP domain

    2. NM_202285.2 → NP_974014.1  squamosa promoter binding protein-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7A9, Q9SMX8
      UniProtKB/TrEMBL
      A0A178WEY0, A0A5S9WRD5
      Conserved Domains (1) summary
      pfam03110
      Location:54 → 128
      SBP; SBP domain

    3. NM_001333580.1 → NP_001321935.1  squamosa promoter binding protein-like 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WCU7, A0A1P8ASL5, A0A384L440
      Conserved Domains (1) summary
      pfam03110
      Location:54 → 128
      SBP; SBP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7A9.1

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