MEA SET domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MEA
Official Full Name: SET domain-containing protein
Primary source: TAIR:AT1G02580
Locus tag: AT1G02580
See related: Araport:AT1G02580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EMB173; EMBRYO DEFECTIVE 173; FERTILIZATION INDEPENDENT SEED 1; FIS1; MEDEA; SDG5; SET DOMAIN-CONTAINING PROTEIN 5; T14P4.11; T14P4_11
Summary: Encodes a putative transcription factor MEDEA (MEA) that negatively regulates seed development in the absence of fertilization. Mutations in this locus result in embryo lethality. MEA is a Polycomb group gene that is imprinted in the endosperm. The maternal allele is expressed and the paternal allele is silent. MEA is controlled by DEMETER (DME), a DNA glycosylase required to activate MEA expression, and METHYLTRANSFERASE I (MET1), which maintains CG methylation at the MEA locus. MEA is involved in the negative regulation of its own imprinted gene expression; the effect is not only allele-specific but also dynamically regulated during seed development. In the ovule, the MEA transcripts are accumulated at their highest level before fertilization and gradually decrease after fertilization
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Genomic context

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See MEA in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 17

Sequence:: Chromosome: 1; NC_003070.9 (544733..549202)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEA role and expression in the pathogen defense.
Title: The Polycomb-Group Repressor MEDEA Attenuates Pathogen Defense.
Evidence indicates that FIS2 and MEA have diverged in concert, resulting in functional divergence of the PRC2 complexes in Brassicaceae. This type of concerted divergence is a previously unreported fate of duplicated genes. In addition, the Brassicaceae-specific FIS-PRC2 complex modified the regulatory pathways in female gametophyte and seed development. [MEA]
Title: FERTILIZATION-INDEPENDENT SEED-Polycomb Repressive Complex 2 Plays a Dual Role in Regulating Type I MADS-Box Genes in Early Endosperm Development.
TAF13 functions together with MEDEA and SWINGER, both members of a plant variant of Polycomb Repressive Complex 2 (PRC2)in transcriptional regulation during seed development. [MEDEA]
Title: TAF13 interacts with PRC2 members and is essential for Arabidopsis seed development.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Title: The Polycomb group protein MEDEA and the DNA methyltransferase MET1 interact to repress autonomous endosperm development in Arabidopsis.
functional requirement of the FIS-PRC2 is to balance parental genome contributions and to reduce genetic conflict.
Title: Increased maternal genome dosage bypasses the requirement of the FIS polycomb repressive complex 2 in Arabidopsis seed development.
imprinted MEA expression mediated by this ICR is independent of DME and MET1, consistent with the lack of any significant DNA methylation in this region
Title: Identification of a DNA methylation-independent imprinting control region at the Arabidopsis MEDEA locus.
CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting.
Title: The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting.
Parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions.
Title: Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis.
Study presents data and analyses of sequence diversity of MEA in self-fertilizing and outcrossing Arabidopsis and its relatives, to help clarify the form of selection acting on this gene.
Title: Possible diversifying selection in the imprinted gene, MEDEA, in Arabidopsis.
Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
Title: Detection of protein-protein interactions in plants using bimolecular fluorescence complementation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone H3 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epigenetic programming in the endosperm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of endosperm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to absence of light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within seed morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SET domain-containing protein

NP_563658.1

MEDEA (MEA); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), SET domain (InterPro:IPR001214); BEST Arabidopsis thaliana protein match is: SET domain-containing protein (TAIR:AT4G02020.1); Has 4870 Blast hits to 4762 proteins in 465 species: Archae - 0; Bacteria - 401; Metazoa - 1924; Fungi - 484; Plants - 1009; Viruses - 0; Other Eukaryotes - 1052 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

544733..549202

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100139.4 → NP_563658.1 SET domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563658.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65312

UniProtKB/TrEMBL

C0KG99

Conserved Domains (1) summary

smart00317
Location:544 → 660

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001331345.1 → NP_001322965.1 SET domain-containing protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AVN9, A7UIR6