cICDH cytosolic NADP+-dependent isocitrate dehydrogenase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: cICDH
Official Full Name: cytosolic NADP+-dependent isocitrate dehydrogenase
Primary source: TAIR:AT1G65930
Locus tag: AT1G65930
See related: Araport:AT1G65930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cytosolic NADP+-dependent isocitrate dehydrogenase; F12P19.10; F12P19_10
Summary: Encodes a NADP+-isocitrate dehydrogenase that is believed to function in the cytosol. It appears to contribute to NADPH production under oxidative stress, and thereby to participate in redox signalling linked to defense responses.
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Genomic context

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See cICDH in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 15

Sequence:: Chromosome: 1; NC_003070.9 (24538886..24542712)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A substantial reduction in leaf isocitrate dehydrogenase activity did not lead to changes in the respiration efflux rate but respiratory metabolism was reorchestrated:2OG production was supplemented by a metabolic bypass involving both lysine synthesis and degradation. [ICDH2]
Title: A new anaplerotic respiratory pathway involving lysine biosynthesis in isocitrate dehydrogenase-deficient Arabidopsis mutants.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_105265.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	HDA more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within NADP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within isocitrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: cytosolic NADP+-dependent isocitrate dehydrogenase

NP_176768.1

cytosolic NADP+-dependent isocitrate dehydrogenase (cICDH); FUNCTIONS IN: isocitrate dehydrogenase (NADP+) activity, copper ion binding; INVOLVED IN: in 7 processes; LOCATED IN: cytosol, apoplast, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NADP-dependent, eukaryotic (InterPro:IPR004790), Isocitrate/isopropylmalate dehydrogenase, conserved site (InterPro:IPR019818); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase (TAIR:AT1G54340.1); Has 5437 Blast hits to 5413 proteins in 1130 species: Archae - 48; Bacteria - 1243; Metazoa - 817; Fungi - 231; Plants - 475; Viruses - 0; Other Eukaryotes - 2623 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24538886..24542712

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105265.5 → NP_176768.1 cytosolic NADP+-dependent isocitrate dehydrogenase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176768.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L9Z4, Q8RWH2, Q8RYD5, Q9SRZ6

UniProtKB/TrEMBL

A0A178W7K0, A0A5S9WSA6

Conserved Domains (1) summary

PLN00103
Location:1 → 408

PLN00103; isocitrate dehydrogenase (NADP+); Provisional