C1qtnf12 C1q and tumor necrosis factor related 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1qtnf12provided by MGI
Official Full Name: C1q and tumor necrosis factor related 12provided by MGI
Primary source: MGI:MGI:1914639
See related: Ensembl:ENSMUSG00000023571 AllianceGenome:MGI:1914639
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C1qdc2; CTRP12; Fam132a; alipolin; 1110035L05Rik
Summary: Enables hormone activity. Involved in regulation of D-glucose import. Acts upstream of or within several processes, including negative regulation of gluconeogenesis; positive regulation of D-glucose import; and positive regulation of cell communication. Located in extracellular space. Is expressed in cochlea; genitourinary system; liver lobe; thyroid gland; and vibrissa. Orthologous to human C1QTNF12 (C1q and TNF related 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 84.1), adrenal adult (RPKM 49.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 87.66 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156046769..156051086)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155962312..155966629)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTRP12 alleviates cardiomyocyte ischemiareperfusion injury via regulation of KLF15.
Title: CTRP12 alleviates cardiomyocyte ischemia‑reperfusion injury via regulation of KLF15.
Up-regulation of CTRP12 ameliorates hypoxia/re-oxygenation-induced cardiomyocyte injury by inhibiting apoptosis, oxidative stress, and inflammation via the enhancement of Nrf2 signaling.
Title: Up-regulation of CTRP12 ameliorates hypoxia/re-oxygenation-induced cardiomyocyte injury by inhibiting apoptosis, oxidative stress, and inflammation via the enhancement of Nrf2 signaling.
CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRalpha pathway.
Title: CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway.
CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4alpha and DGAT2 expression.
Title: CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4α and DGAT2 expression.
CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice.
Title: CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice.
Adipolin/CTRP12 protects against pathological vascular remodelling through suppression of smooth muscle cell growth and macrophage inflammatory response.
Title: Adipolin/CTRP12 protects against pathological vascular remodelling through suppression of smooth muscle cell growth and macrophage inflammatory response.
Loss of a single Ctrp12 allele affects glucose and lipid metabolism.
Title: Partial deficiency of CTRP12 alters hepatic lipid metabolism.
Adipolin is transcriptionally regulated by KLF15 in adipocytes.
Title: Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15.
mRNA expression of Fam132a, which encodes a newly identified insulin-sensitizing adipokine, adipolin, is significantly upregulated in the absence of KLF3.
Title: Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).
These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue.
Title: Regulation of adipolin/CTRP12 cleavage by obesity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adipolin

Names: C1q domain containing 2; adipose-derived insulin-sensitizing factor; complement C1q tumor necrosis factor-related protein 12; family with sequence similarity 132, member A; protein FAM132A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.