Ifngr2 interferon gamma receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifngr2provided by MGI
Official Full Name: interferon gamma receptor 2provided by MGI
Primary source: MGI:MGI:107654
See related: Ensembl:ENSMUSG00000022965 AllianceGenome:MGI:107654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifgt; Ifgr2
Summary: Predicted to enable type II interferon receptor activity. Acts upstream of or within defense response to virus. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 28. Orthologous to human IFNGR2 (interferon gamma receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 148.1), small intestine adult (RPKM 81.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 53.07 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91343947..91360895)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91547059..91564007)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myeloid cell IFNGR2 deficiency does not affect atherosclerosis development in LDLR knockout mice.
Title: Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.
We show that demyelination in response to cuprizone is delayed in mice lacking the binding chain of IFNgamma receptor. In addition, IFNgammaR(-/-) mice exhibited an accelerated remyelination process after cuprizone was removed from the diet.
Title: Deleterious role of IFNgamma in a toxic model of central nervous system demyelination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifngr2 (e-PCR), detects polymorphism
- UniSTS:546830

Ifngr2 (e-PCR), detects polymorphism
- UniSTS:259092

Ifngr2 (e-PCR), detects polymorphism
- UniSTS:259621

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type II interferon receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in type III interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon gamma receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008338.4 → NP_032364.1 interferon gamma receptor 2 precursor

See identical proteins and their annotated locations for NP_032364.1

Status: VALIDATED

Source sequence(s)

AC159199

Consensus CDS

CCDS28327.1

UniProtKB/TrEMBL

Q3UVK9, Q63953

Related

ENSMUSP00000023687.8, ENSMUST00000023687.9

Conserved Domains (2) summary

pfam01108
Location:24 → 121

Tissue_fac; Tissue factor

cl21522
Location:134 → 233

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...