Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chrna6provided by MGI
Official Full Name: cholinergic receptor, nicotinic, alpha polypeptide 6provided by MGI
Primary source: MGI:MGI:106213
See related: Ensembl:ENSMUSG00000031491 AllianceGenome:MGI:106213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acra6; Nica6
Summary: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine abuse; and nicotine dependence. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 16.02 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (27893240..27903972, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (27403212..27413944, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bidirectional sex-dependent regulation of alpha6 and beta3 nicotinic acetylcholine receptors by protein kinase Cepsilon.
Title: Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε.
study provides evidence that alpha6beta2 nAChRs are involved in locomotor activity as well as ethanol and saccharin consumption in adolescent animals
Title: α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption.
Using behavioral and cellular measures of alpha6 * nAChR function, study demonstrated that the ventral tegmental area is a key site of action for nicotine at alpha6 * nAChRs
Title: α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
The present data show that alpha6beta2( *) nAChRs are key regulators of LIDs, and may be useful therapeutic targets for their management in Parkinson's disease.
Title: Evidence for a role for α6(∗) nAChRs in l-dopa-induced dyskinesias using Parkinsonian α6(∗) nAChR gain-of-function mice.
these data indicate that a6)nAChR do not have an impact on motor output.
Title: A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior.
enhanced alpha6beta2* nAChR activity in nucleus accumbens can stimulate dopamine production
Title: Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function α6* nAChRs.
Chrna6 expression decreases with death of RGCs in glaucomatous DBA/2J mice and after optic nerve crush injury, further supporting Chrna6 as a reliable RGC marker.
Title: Effects of glaucoma on Chrna6 expression in the retina.
While the Chrna6 gene did not significantly influence ethanol consumption (g/kg) or ataxia, mice lacking the alpha6 subunit took significantly longer to recover their righting reflex than WT animals
Title: The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation.
The superior colliculus is responsible for transmitting short-latency salience signals to thalamus and midbrain DA neurons. these results suggest that alpha6* nAChRs may be important for nicotinic cholinergic sensitization of this pathway.
Title: α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.
beta3 subunit coexpression promotes function of alpha6*-nAChR
Title: Modulation of gain-of-function α6*-nicotinic acetylcholine receptor by β3 subunits.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

Chrna6 (e-PCR), detects polymorphism
- UniSTS:256424

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-6

Names: acetylcholine receptor alpha 6 neural; alpha6 nAChR; nicotinic acetylcholine receptor subunit alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021369.2 → NP_067344.2 neuronal acetylcholine receptor subunit alpha-6 precursor

See identical proteins and their annotated locations for NP_067344.2

Status: VALIDATED

Source sequence(s)

BC031985

Consensus CDS

CCDS40312.1

UniProtKB/Swiss-Prot

Q3UEY4, Q8K0A7, Q9R0W9

UniProtKB/TrEMBL

Q6PW44

Related

ENSMUSP00000033882.9, ENSMUST00000033882.10

Conserved Domains (3) summary

TIGR00860
Location:15 → 484

LIC; Cation transporter family protein

pfam02931
Location:34 → 240

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:247 → 483

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region