Clic6 chloride intracellular channel 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clic6provided by MGI
Official Full Name: chloride intracellular channel 6provided by MGI
Primary source: MGI:MGI:2146607
See related: Ensembl:ENSMUSG00000022949 AllianceGenome:MGI:2146607
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLIC1L; 5730466J16Rik
Summary: Predicted to enable chloride channel activity; dopamine receptor binding activity; and identical protein binding activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of chloride channel complex. Is expressed in several structures, including cardiovascular system; central nervous system; gut; sensory organ; and urinary system. Orthologous to human CLIC6 (chloride intracellular channel 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 15.5), placenta adult (RPKM 13.6) and 14 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16 C4; 16 53.64 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (92295035..92338129)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (92498147..92541241)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biophysical characterization of chloride intracellular channel 6 (CLIC6).
Title: Biophysical characterization of chloride intracellular channel 6 (CLIC6).

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

Go to the top of the page Help

Markers

AW045520 (e-PCR)
- UniSTS:166021

RH125377 (e-PCR)
- UniSTS:162199

RH125406 (e-PCR)
- UniSTS:162228

5730466J16Rik (e-PCR), detects polymorphism
- UniSTS:259027

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D2 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D2 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D3 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D3 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D4 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D4 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: chloride intracellular channel protein 6

Names: glutaredoxin-like oxidoreductase CLIC6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172469.3 → NP_766057.1 chloride intracellular channel protein 6

See identical proteins and their annotated locations for NP_766057.1

Status: PROVISIONAL

Source sequence(s)

AC174448

Consensus CDS

CCDS28338.1

UniProtKB/Swiss-Prot

Q8BHB9

Related

ENSMUSP00000023670.4, ENSMUST00000023670.4

Conserved Domains (4) summary

TIGR00862
Location:363 → 596

O-ClC; intracellular chloride channel protein

PHA02664
Location:69 → 167

PHA02664; hypothetical protein; Provisional

cd10301
Location:455 → 594

GST_C_CLIC6; C-terminal, alpha helical domain of Chloride Intracellular Channel 6

cd03061
Location:360 → 448

GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...