Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf1bprovided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 1bprovided by MGI
Primary source: MGI:MGI:1314883
See related: Ensembl:ENSMUSG00000028599 AllianceGenome:MGI:1314883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2
Summary: Enables tumor necrosis factor receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system; liver; and trunk. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 20.1), mammary gland adult (RPKM 14.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 78.17 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (144938938..144973453, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (145212368..145246870, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis.
Title: Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis.
Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
Title: Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
TNF-alpha-TNFR1 Signaling Mediates Inflammation and Bone Resorption in Apical Periodontitis.
Title: TNF-α-TNFR1 Signaling Mediates Inflammation and Bone Resorption in Apical Periodontitis.
The TNFalpha/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.
Title: The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.
Single-cell transcriptomics identify TNFRSF1B as a novel T-cell exhaustion marker for ovarian cancer.
Title: Single-cell transcriptomics identify TNFRSF1B as a novel T-cell exhaustion marker for ovarian cancer.
Aging and TNF induce premature senescence of astrocytes after spinal cord injury via regulating YAP expression.
Title: Aging and TNF induce premature senescence of astrocytes after spinal cord injury via regulating YAP expression.
IL-10 in combination with IL-12 and TNF-alpha attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway.
Title: IL-10 in combination with IL-12 and TNF-α attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-κB pathway.
TNFR2 deficiency impairs the growth of mouse colon cancer.
Title: TNFR2 deficiency impairs the growth of mouse colon cancer.
Loss of tumor necrosis factor (TNF)-receptor 1 and TNF-receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus.
Title: Loss of tumor necrosis factor (TNF)-receptor 1 and TNF-receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus.
Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice.
Title: Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (182)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnfrsf1a (e-PCR), detects polymorphism
- UniSTS:144654

Tnfrsf1b (e-PCR), detects polymorphism
- UniSTS:144655

Tnfrsf1b (e-PCR), detects polymorphism
- UniSTS:144656

Tnfrsf1b (e-PCR), detects polymorphism
- UniSTS:257054

Tnfrsf1b (e-PCR), detects polymorphism
- UniSTS:525677

D4Mit233 (e-PCR), detects polymorphism
- UniSTS:130017

PMC224571P2 (e-PCR)
- UniSTS:272110

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aortic valve development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell-neuron signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle hypertrophy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extracellular matrix constituent secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroinflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pulmonary valve development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of T cell cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of myelination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroinflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in varicosity	IEA Inferred from Electronic Annotation more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 1B

Names: TNF receptor beta chain; TNF-RII; TNFR-II; p75 TNFR; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011610.3 → NP_035740.2 tumor necrosis factor receptor superfamily member 1B precursor

See identical proteins and their annotated locations for NP_035740.2

Status: VALIDATED

Source sequence(s)

AK140332, BY489212

Consensus CDS

CCDS18914.1

UniProtKB/Swiss-Prot

O88734, P25119, P97893

UniProtKB/TrEMBL

Q3U2A9, Q545P4

Related

ENSMUSP00000030336.5, ENSMUST00000030336.11

Conserved Domains (1) summary

cd10577
Location:40 → 203

TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

144938938..144973453 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163965.1 → XP_036019858.1 tumor necrosis factor receptor superfamily member 1B isoform X1

Conserved Domains (3) summary

COG3889
Location:69 → 138

COG3889; Predicted periplasmic protein [Function unknown]

cd00185
Location:24 → 64

TNFRSF; CRD4 [structural motif]

cl22855
Location:1 → 64

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)