Stx5a syntaxin 5A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx5aprovided by MGI
Official Full Name: syntaxin 5Aprovided by MGI
Primary source: MGI:MGI:1928483
See related: Ensembl:ENSMUSG00000010110 AllianceGenome:MGI:1928483
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stx5; D19Ertd627e; 0610031F24Rik
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and regulation of Golgi organization. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and vesicle. Predicted to be part of SNARE complex. Predicted to be active in Golgi membrane. Is expressed in mesenchyme of metanephros and metanephros epithelium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 35.3), ovary adult (RPKM 26.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.45 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8718788..8733006)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8741424..8755642)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stx5 is an autophagy target that is inefficiently membrane-targeted by alternative pathways; mice without WRB have different biogenesis requirements for tail anchored proteins
Title: Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.
Pkd2 in the ER plays a role in cellular Ca(2+) homeostasis and Stx5 functions to inactivate Pkd2 and prevent leaking of Ca(2+) from ER stores
Title: Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE457658 (e-PCR)
- UniSTS:209437

AU014962 (e-PCR)
- UniSTS:167250

RH124618 (e-PCR)
- UniSTS:161440

RH125702 (e-PCR)
- UniSTS:162471

H31976 (e-PCR)
- UniSTS:261042

RH134005 (e-PCR)
- UniSTS:217287

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi disassembly	ISO Inferred from Sequence Orthology more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion with Golgi apparatus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	TAS Traceable Author Statement more info	PubMed
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167799.1 → NP_001161271.1 syntaxin-5

See identical proteins and their annotated locations for NP_001161271.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

BQ030996, CK389576, CN539678, DV649852

Consensus CDS

CCDS29542.2

UniProtKB/Swiss-Prot

Q3TM79, Q8K1E0, Q99J28, Q9JKP2

Related

ENSMUSP00000134854.2, ENSMUST00000176381.8

Conserved Domains (3) summary

COG5325
Location:94 → 324

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15844
Location:266 → 338

SNARE_syntaxin5; SNARE motif of syntaxin 5

pfam11416
Location:53 → 74

Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
NM_019829.4 → NP_062803.4 syntaxin-5

See identical proteins and their annotated locations for NP_062803.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AC025794, BQ030996, CN539678, DV649852

Consensus CDS

CCDS29542.2

UniProtKB/Swiss-Prot

Q3TM79, Q8K1E0, Q99J28, Q9JKP2

Related

ENSMUSP00000073136.8, ENSMUST00000073430.14

Conserved Domains (3) summary

COG5325
Location:94 → 324

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15844
Location:266 → 338

SNARE_syntaxin5; SNARE motif of syntaxin 5

pfam11416
Location:53 → 74

Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

8718788..8733006

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251000.2 → XP_030106860.1 syntaxin-5 isoform X1

UniProtKB/Swiss-Prot

Q3TM79, Q8K1E0, Q99J28, Q9JKP2

Conserved Domains (3) summary

COG5325
Location:94 → 324

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15844
Location:266 → 338

SNARE_syntaxin5; SNARE motif of syntaxin 5

pfam11416
Location:53 → 74

Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
XM_030250998.2 → XP_030106858.1 syntaxin-5 isoform X1

UniProtKB/Swiss-Prot

Q3TM79, Q8K1E0, Q99J28, Q9JKP2

Conserved Domains (3) summary

COG5325
Location:94 → 324

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15844
Location:266 → 338

SNARE_syntaxin5; SNARE motif of syntaxin 5

pfam11416
Location:53 → 74

Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
XM_030250999.2 → XP_030106859.1 syntaxin-5 isoform X1

UniProtKB/Swiss-Prot

Q3TM79, Q8K1E0, Q99J28, Q9JKP2

Conserved Domains (3) summary

COG5325
Location:94 → 324

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15844
Location:266 → 338

SNARE_syntaxin5; SNARE motif of syntaxin 5

pfam11416
Location:53 → 74

Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain