Tnn tenascin N [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnnprovided by MGI
Official Full Name: tenascin Nprovided by MGI
Primary source: MGI:MGI:2665790
See related: Ensembl:ENSMUSG00000026725 AllianceGenome:MGI:2665790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tnw; TN-W; tenascin-W
Summary: Enables identical protein binding activity and integrin binding activity. Involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway; and negative regulation of osteoblast differentiation. Acts upstream of or within axonogenesis and cell-matrix adhesion. Located in several cellular components, including CA3 pyramidal cell dendrite; hippocampal mossy fiber expansion; and neuronal cell body. Part of tenascin complex. Is expressed in several structures, including cranium; dura mater; forelimb; palatal shelf; and periosteum. Orthologous to human TNN (tenascin N). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 2.1), limb E14.5 (RPKM 1.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 69.4 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (159912599..159981242, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (160085029..160153692, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNN is first linked to auditory neuropathy.
Title: TNN is first linked to auditory neuropathy.
Pivotal Role of Tenascin-W (-N) in Postnatal Incisor Growth and Periodontal Ligament Remodeling.
Title: Pivotal Role of Tenascin-W (-N) in Postnatal Incisor Growth and Periodontal Ligament Remodeling.
TN-C may enhance inflammatory responses by accelerating macrophage migration and synthesis of proinflammatory/profibrotic cytokines via integrin alphaVbeta3/FAK-Src/NF-kappaB, resulting in increased fibrosis.
Title: Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin αVβ3/nuclear factor-κB/interleukin-6 axis.
Results show that tenascin-W acts as a niche component for breast cancer metastasis to bone by supporting cell migration and cell proliferation of the cancer cells.
Title: Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells.
the CD34-positive whisker follicle stem cell niche contains both tenascin-C and tenascin-W, and these glycoproteins might play a role in directing the migration and proliferation of these stem cells
Title: Tenascin-C and tenascin-W in whisker follicle stem cell niches: possible roles in regulating stem cell proliferation and migration.
Tenascin-W is able to inhibit cell spreading in vitro and it is upregulated in dermal fibroblasts taken from a tenascin-C knockout mouse.
Title: The adhesion modulating properties of tenascin-W.
Tenascin-W is expressed during palate formation, osteogenesis and smooth muscle development.
Title: Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development.
Our results indicate that TN-W is a novel marker of preosteoblasts in early stage of osteogenesis, and that TN-W inhibits cell proliferation and differentiation of preosteoblasts mediated by canonical Wnt signaling.
Title: Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

D1Pgn1 (e-PCR), detects polymorphism
- UniSTS:265647

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite self-avoidance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection extension	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle tissue development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in CA3 pyramidal cell dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in hippocampal mossy fiber expansion	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of tenascin complex	IPI Inferred from Physical Interaction more info	PubMed
part_of tenascin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tenascin-N

Names: TN-N; tenasin W

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177839.3 → NP_808507.2 tenascin-N precursor

See identical proteins and their annotated locations for NP_808507.2

Status: VALIDATED

Source sequence(s)

AK048033, BC138335, BY722860, CD773844

Consensus CDS

CCDS15404.1

UniProtKB/Swiss-Prot

B9EHR3, Q70HX0, Q80Z71

UniProtKB/TrEMBL

E9Q1F6

Related

ENSMUSP00000039452.6, ENSMUST00000039178.12

Conserved Domains (6) summary

smart00060
Location:532 → 608

FN3; Fibronectin type 3 domain

cd00063
Location:444 → 529

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1327 → 1539

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam18720
Location:171 → 198

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:264 → 332

fn3; Fibronectin type III domain

pfam07974
Location:236 → 259

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

159912599..159981242 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496904.2 → XP_006496967.1 tenascin-N isoform X1

UniProtKB/TrEMBL

E9Q1F6

Conserved Domains (4) summary

cd00087
Location:1239 → 1451

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam07974
Location:233 → 259

EGF_2; EGF-like domain

pfam00041
Location:264 → 342

fn3; Fibronectin type III domain

pfam18720
Location:171 → 198

EGF_Tenascin; Tenascin EGF domain
XM_006496906.2 → XP_006496969.1 tenascin-N isoform X2

UniProtKB/TrEMBL

E9Q1F6

Related

ENSMUSP00000115685.2, ENSMUST00000131919.2

Conserved Domains (4) summary

cd00087
Location:1239 → 1451

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam07974
Location:233 → 259

EGF_2; EGF-like domain

pfam00041
Location:264 → 342

fn3; Fibronectin type III domain

pfam18720
Location:171 → 198

EGF_Tenascin; Tenascin EGF domain