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    MTHFR2 methylenetetrahydrofolate reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819022, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MTHFR2
    Official Full Name
    methylenetetrahydrofolate reductase 2
    Primary source
    TAIR:AT2G44160
    Locus tag
    AT2G44160
    See related
    Araport:AT2G44160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6E13.29; methylenetetrahydrofolate reductase 2
    Summary
    methylenetetrahydrofolate reductase MTHFR2 mRNA, complete
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    Genomic context

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    See MTHFR2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (18262189..18265346)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Peptidase family C54 protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene histone-lysine N-methyltransferase ASHH3 Neighboring gene miscRNA Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene methionine aminopeptidase 2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    3. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129979.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in methionine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methylenetetrahydrofolate reductase 2
    NP_566011.1
    • methylenetetrahydrofolate reductase 2 (MTHFR2); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: male gametophyte, guard cell, cultured cell, leaf; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 1 (TAIR:AT3G59970.3); Has 4605 Blast hits to 4574 proteins in 1845 species: Archae - 16; Bacteria - 3444; Metazoa - 135; Fungi - 300; Plants - 75; Viruses - 0; Other Eukaryotes - 635 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18262189..18265346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129979.3 → NP_566011.1  methylenetetrahydrofolate reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80585, Q56ZL2, Q94JZ1, Q9SE59, Q9SUJ0
      UniProtKB/TrEMBL
      A0A5S9X752
      Conserved Domains (1) summary
      PLN02540
      Location:18 → 582
      PLN02540; methylenetetrahydrofolate reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80585.2

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