U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mfsd4a major facilitator superfamily domain containing 4A [ Mus musculus (house mouse) ]

    Gene ID: 213006, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mfsd4aprovided by MGI
    Official Full Name
    major facilitator superfamily domain containing 4Aprovided by MGI
    Primary source
    MGI:MGI:2442786
    See related
    Ensembl:ENSMUSG00000059149 AllianceGenome:MGI:2442786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfsd4; A230072B04; A930031D07Rik
    Summary
    Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD4A (major facilitator superfamily domain containing 4A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 40.5), adrenal adult (RPKM 15.7) and 17 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mfsd4a in Genome Data Viewer
    Location:
    1 E4; 1 57.24 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131947543..131997400, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132022806..132069658, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene ELK4, member of ETS oncogene family Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998691-133998892 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998935-133999044 Neighboring gene predicted gene, 37120

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Kerr N, et al. Mol Cell Neurosci, 2010 Jun. PMID 20304071, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    major facilitator superfamily domain-containing protein 4A
    Names
    major facilitator superfamily domain containing 4
    major facilitator superfamily domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114662.1 → NP_001108134.1  major facilitator superfamily domain-containing protein 4A isoform b

      See identical proteins and their annotated locations for NP_001108134.1

      Status: VALIDATED

      Source sequence(s)
      AC107837, AI642828, AK048692, AK085484, AK162495
      Consensus CDS
      CCDS48357.1
      UniProtKB/Swiss-Prot
      Q6PDC8, Q8C3M3, Q8C816, Q8CAF5
      UniProtKB/TrEMBL
      E0CX35
      Related
      ENSMUSP00000125558.2, ENSMUST00000159038.8
      Conserved Domains (2) summary
      cd06174
      Location:298 → 480
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:22 → 442
      MFS_1; Major Facilitator Superfamily

    2. NM_172510.4 → NP_766098.2  major facilitator superfamily domain-containing protein 4A isoform a

      See identical proteins and their annotated locations for NP_766098.2

      Status: VALIDATED

      Source sequence(s)
      AK048692, AK162495
      Consensus CDS
      CCDS15280.2
      UniProtKB/TrEMBL
      F8WIG8
      Related
      ENSMUSP00000107989.3, ENSMUST00000112370.9
      Conserved Domains (1) summary
      cd17453
      Location:18 → 479
      MFS_MFSD4A; Major facilitator superfamily domain-containing protein 4A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131947543..131997400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529345.5 → XP_006529408.1  major facilitator superfamily domain-containing protein 4A isoform X2

      See identical proteins and their annotated locations for XP_006529408.1

      UniProtKB/Swiss-Prot
      Q6PDC8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 257
      MFS; Major Facilitator Superfamily

    2. XM_030252744.2 → XP_030108604.1  major facilitator superfamily domain-containing protein 4A isoform X1

      UniProtKB/TrEMBL
      F8WIG8
      Related
      ENSMUSP00000116282.3, ENSMUST00000144548.9
      Conserved Domains (1) summary
      cd17453
      Location:18 → 479
      MFS_MFSD4A; Major facilitator superfamily domain-containing protein 4A

    3. XM_017319650.3 → XP_017175139.1  major facilitator superfamily domain-containing protein 4A isoform X2

      UniProtKB/Swiss-Prot
      Q6PDC8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 257
      MFS; Major Facilitator Superfamily

    4. XM_006529344.5 → XP_006529407.1  major facilitator superfamily domain-containing protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006529407.1

      UniProtKB/TrEMBL
      F8WIG8
      Related
      ENSMUSP00000116706.2, ENSMUST00000126927.8
      Conserved Domains (1) summary
      cd17453
      Location:18 → 479
      MFS_MFSD4A; Major facilitator superfamily domain-containing protein 4A

    5. XM_030252750.2 → XP_030108610.1  major facilitator superfamily domain-containing protein 4A isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:1 → 257
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_001783717.3 RNA Sequence

    2. XR_001783716.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDC8.2 GenPept UniProtKB/Swiss-Prot:Q6PDC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools