Zcwpw1 zinc finger, CW type with PWWP domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zcwpw1provided by MGI
Official Full Name: zinc finger, CW type with PWWP domain 1provided by MGI
Primary source: MGI:MGI:2685899
See related: Ensembl:ENSMUSG00000037108 AllianceGenome:MGI:2685899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1053
Summary: Enables histone reader activity and methylated histone binding activity. Involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Acts upstream of or within homologous chromosome pairing at meiosis. Located in XY body and nucleus. Is expressed in brain; lung; reproductive system; and thymus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 4.2), testis adult (RPKM 3.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.71 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137785593..137820883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137787157..137822621)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells.
Title: MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells.
The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.
Title: The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.
Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.
Title: Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.
ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
Title: ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
The results suggest that ZCWPW1 may represent a previously unknown, sex-dependent epigenetic regulator of germ cell meiosis in mammals.
Title: The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone reader activity	IDA Inferred from Direct Assay more info	PubMed
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in XY body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger CW-type PWWP domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005426.2 → NP_001005426.2 zinc finger CW-type PWWP domain protein 1

See identical proteins and their annotated locations for NP_001005426.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK080079, BC071186, CF982070

Consensus CDS

CCDS19779.1

UniProtKB/Swiss-Prot

Q2YFS4, Q6IR42

Related

ENSMUSP00000048730.8, ENSMUST00000035852.14

Conserved Domains (3) summary

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 406

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

cl25732
Location:76 → 228

SMC_N; RecF/RecN/SMC N terminal domain
NM_001360023.1 → NP_001346952.1 zinc finger CW-type PWWP domain protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC125063

Consensus CDS

CCDS19779.1

UniProtKB/Swiss-Prot

Q2YFS4, Q6IR42

Conserved Domains (3) summary

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 406

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

cl25732
Location:76 → 228

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137785593..137820883

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254625.2 → XP_030110485.1 zinc finger CW-type PWWP domain protein 1 isoform X3

Conserved Domains (3) summary

pfam05483
Location:76 → 228

SCP-1; Synaptonemal complex protein 1 (SCP-1)

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 375

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
XM_036165244.1 → XP_036021137.1 zinc finger CW-type PWWP domain protein 1 isoform X1

Conserved Domains (2) summary

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 406

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
XM_036165243.1 → XP_036021136.1 zinc finger CW-type PWWP domain protein 1 isoform X1

Conserved Domains (2) summary

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 406

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
XM_036165245.1 → XP_036021138.1 zinc finger CW-type PWWP domain protein 1 isoform X2

Conserved Domains (2) summary

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 375

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
XM_006504585.4 → XP_006504648.1 zinc finger CW-type PWWP domain protein 1 isoform X3

Conserved Domains (3) summary

pfam05483
Location:76 → 228

SCP-1; Synaptonemal complex protein 1 (SCP-1)

pfam07496
Location:247 → 292

zf-CW; CW-type Zinc Finger

cl02554
Location:304 → 375

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
XM_036165246.1 → XP_036021139.1 zinc finger CW-type PWWP domain protein 1 isoform X4

Conserved Domains (1) summary

cl02554
Location:1 → 82

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...