Kcne2 potassium voltage-gated channel, Isk-related subfamily, gene 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcne2provided by MGI
Official Full Name: potassium voltage-gated channel, Isk-related subfamily, gene 2provided by MGI
Primary source: MGI:MGI:1891123
See related: Ensembl:ENSMUSG00000039672 AllianceGenome:MGI:1891123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MiRP1; 2200002I16Rik
Summary: Predicted to enable several functions, including identical protein binding activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to contribute to delayed rectifier potassium channel activity; inward rectifier potassium channel activity; and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in iodide transport; multicellular organismal response to stress; and myo-inositol transport. Acts upstream of or within several processes, including potassium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane repolarization; and ventricular cardiac muscle cell action potential. Located in apical plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in atrial fibrillation; familial atrial fibrillation; long QT syndrome; and long QT syndrome 6. Orthologous to human KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 4.7), stomach adult (RPKM 4.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 53.55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (92089277..92095021)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (92292389..92298133)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.
Title: Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.
The data we present here suggest an important and specific role for Kcne2 in the highly specialized photoreceptor-bipolar cell synapse.
Title: Expression and Localization of Kcne2 in the Vertebrate Retina.
It was concluded that KCNE2 regulates KCNQ1 in the lungs and is required for normal lung function and resistance to pulmonary ischemia/reperfusion injury.
Title: The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury.
Remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death by activation of AKT/ERK1/ERK2 signaling pathway.
Title: AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death.
These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM.
Title: Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus.
Kcne2 deletion preconditions the heart, attenuating the acute tissue damage caused by an imposed ischaemia/reperfusion injury
Title: Kcne2 deletion attenuates acute post-ischaemia/reperfusion myocardial infarction.
The data establish causality for the first example of ion channel-linked atherosclerosis, and demonstrate that the severity of Kcne2-linked cardiac arrhythmias is strongly diet-dependent.
Title: Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death.
Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration.
Title: Manipulation of KCNE2 expression modulates action potential duration and Ito and IK in rat and mouse ventricular myocytes.
Kcne2-deficient mice, in addition to the previously reported phenotypes, also present with iron-deficient anemia.
Title: Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.
KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability.
Title: KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

Kcne2 (e-PCR), detects polymorphism
- UniSTS:259099

Kcne2 (e-PCR), detects polymorphism
- UniSTS:259628

AW048273 (e-PCR)
- UniSTS:166018

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iodide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myo-inositol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily E member 2

Names: minK-related peptide 1; minimum potassium ion channel related peptide 1; potassium channel subunit beta MiRP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358372.1 → NP_001345301.1 potassium voltage-gated channel subfamily E member 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC145550

Consensus CDS

CCDS28333.1

UniProtKB/Swiss-Prot

Q8R1Z7, Q9D808

UniProtKB/TrEMBL

A0A0R4J1J2

Related

ENSMUSP00000109604.2, ENSMUST00000113971.2

Conserved Domains (1) summary

pfam02060
Location:50 → 97

ISK_Channel; Slow voltage-gated potassium channel
NM_134110.3 → NP_598871.1 potassium voltage-gated channel subfamily E member 2

See identical proteins and their annotated locations for NP_598871.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK008619, AW048273

Consensus CDS

CCDS28333.1

UniProtKB/Swiss-Prot

Q8R1Z7, Q9D808

UniProtKB/TrEMBL

A0A0R4J1J2

Related

ENSMUSP00000048849.4, ENSMUST00000047383.10

Conserved Domains (1) summary

pfam02060
Location:50 → 97

ISK_Channel; Slow voltage-gated potassium channel