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    Sugct succinyl-CoA glutarate-CoA transferase [ Mus musculus (house mouse) ]

    Gene ID: 192136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sugctprovided by MGI
    Official Full Name
    succinyl-CoA glutarate-CoA transferaseprovided by MGI
    Primary source
    MGI:MGI:1923221
    See related
    Ensembl:ENSMUSG00000055137 AllianceGenome:MGI:1923221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5033411D12Rik
    Summary
    Predicted to enable succinate-hydroxymethylglutarate CoA-transferase activity. Located in mitochondrion. Used to study glutaric acidemia type 3. Human ortholog(s) of this gene implicated in glutaric acidemia type 3. Orthologous to human SUGCT (succinyl-CoA:glutarate-CoA transferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 8.4), liver adult (RPKM 3.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sugct in Genome Data Viewer
    Location:
    13 A2; 13 5.92 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (17032057..17869380, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (16857472..17694795, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31711 Neighboring gene STARR-seq mESC enhancer starr_33744 Neighboring gene STARR-seq mESC enhancer starr_33745 Neighboring gene STARR-seq mESC enhancer starr_33747 Neighboring gene STARR-seq mESC enhancer starr_33748 Neighboring gene STARR-seq mESC enhancer starr_33749 Neighboring gene STARR-seq mESC enhancer starr_33750 Neighboring gene STARR-seq mESC enhancer starr_33751 Neighboring gene STARR-seq mESC enhancer starr_33754 Neighboring gene CNDP dipeptidase 2 (metallopeptidase M20 family) pseudogene Neighboring gene STARR-seq mESC enhancer starr_33757 Neighboring gene STARR-seq mESC enhancer starr_33758 Neighboring gene STARR-seq mESC enhancer starr_33759 Neighboring gene STARR-seq mESC enhancer starr_33760 Neighboring gene predicted gene, 25020 Neighboring gene choroidermia pseudogene Neighboring gene STARR-seq mESC enhancer starr_33761 Neighboring gene predicted gene, 24873 Neighboring gene STARR-seq mESC enhancer starr_33762 Neighboring gene STARR-positive B cell enhancer ABC_E1869 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:17787115-17787302 Neighboring gene STARR-seq mESC enhancer starr_33763 Neighboring gene predicted gene, 40826 Neighboring gene M-phase specific PLK1 intereacting protein Neighboring gene microRNA 466i Neighboring gene cyclin dependent kinase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Niska-Blakie J, et al. Cell Mol Life Sci, 2020 Sep. PMID 31722069, Free PMC Article
    2. Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains. Leandro J, et al. Mol Genet Metab, 2021 Feb. PMID 33483254
    3. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. Nakabayashi K, et al. Genomics, 2002 Feb. PMID 11829489
    4. Expression profiles of active genes in human and mouse livers. Kawamoto S, et al. Gene, 1996 Sep 26. PMID 8863742
    5. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.
      Title: Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.
    2. Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
      Title: Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables succinate-hydroxymethylglutarate CoA-transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-hydroxymethylglutarate CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate-hydroxymethylglutarate CoA-transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    succinate--hydroxymethylglutarate CoA-transferase
    Names
    succinylCoA:glutarate-CoA transferase
    NP_619595.3
    XP_011242592.1
    XP_036013805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138654.3 → NP_619595.3  succinate--hydroxymethylglutarate CoA-transferase

      See identical proteins and their annotated locations for NP_619595.3

      Status: VALIDATED

      Source sequence(s)
      AA108199, AC154368, AK160265, CJ068463
      Consensus CDS
      CCDS26252.1
      UniProtKB/Swiss-Prot
      G3X9F8, Q7TNE1
      UniProtKB/TrEMBL
      Q3TV98
      Related
      ENSMUSP00000070759.5, ENSMUST00000068545.6
      Conserved Domains (1) summary
      COG1804
      Location:34 → 430
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      17032057..17869380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157912.1 → XP_036013805.1  succinate--hydroxymethylglutarate CoA-transferase isoform X1

      UniProtKB/TrEMBL
      Q3TV98
      Conserved Domains (1) summary
      COG1804
      Location:32 → 388
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    2. XM_011244290.4 → XP_011242592.1  succinate--hydroxymethylglutarate CoA-transferase isoform X2

      UniProtKB/TrEMBL
      Q3TV98
      Conserved Domains (1) summary
      pfam02515
      Location:39 → 377
      CoA_transf_3; CoA-transferase family III
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNE1.2 GenPept UniProtKB/Swiss-Prot:Q7TNE1

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