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    ER Leucine-rich receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817173, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ER
    Official Full Name
    Leucine-rich receptor-like protein kinase family protein
    Primary source
    TAIR:AT2G26330
    Locus tag
    AT2G26330
    See related
    Araport:AT2G26330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ERECTA; QRP1; QUANTITATIVE RESISTANCE TO PLECTOSPHAERELLA 1; T1D16.3; T1D16_3
    Summary
    Homologous to receptor protein kinases. Involved in specification of organs originating from the shoot apical meristem. Contains a cytoplasmic protein kinase catalytic domain, a transmembrane region, and an extracellular leucine-rich repeat. ER has been identified as a quantitative trait locus for transpiration efficiency by influencing epidermal and mesophyll development, stomatal density and porosity of leaves. It has been implicated in resistance to the bacterium Ralstonia solanacearum and to the necrotrophic fungus Plectosphaerella cucumerina. Together with ERL1 and ERL2, ER governs the initial decision of protodermal cells to either divide proliferatively to produce pavement cells or divide asymmetrically to generate stomatal complexes.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    27
    Sequence:
    Chromosome: 2; NC_003071.7 (11208080..11214662, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Chalcone-flavanone isomerase family protein Neighboring gene AGAMOUS-like 33 Neighboring gene uncharacterized protein Neighboring gene peroxin 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of critical functional residues of receptor-like kinase ERECTA. Kosentka PZ, et al. J Exp Bot, 2017 Mar 1. PMID 28207053, Free PMC Article
    2. ERECTA, salicylic acid, abscisic acid, and jasmonic acid modulate quantitative disease resistance of Arabidopsis thaliana to Verticillium longisporum. Häffner E, et al. BMC Plant Biol, 2014 Apr 1. PMID 24690463, Free PMC Article
    3. The receptor-like kinase ERECTA contributes to the shade-avoidance syndrome in a background-dependent manner. Kasulin L, et al. Ann Bot, 2013 May. PMID 23444123, Free PMC Article
    4. Natural variation identifies multiple loci controlling petal shape and size in Arabidopsis thaliana. Abraham MC, et al. PLoS One, 2013. PMID 23418598, Free PMC Article
    5. [Study of the effect of the gene ERECTA2 on the development of Arabidopsis thaliana shoot]. Soltabaeva AD, et al. Ontogenez, 2013 Nov-Dec. PMID 25438591

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic regulation of female germline development through ERECTA signaling pathway.
      Title: Epigenetic regulation of female germline development through ERECTA signaling pathway.
    2. A non-canonical function of Arabidopsis ERECTA proteins and a role of the SWI3B subunit of the SWI/SNF chromatin remodeling complex in gibberellin signaling.
      Title: A non-canonical function of Arabidopsis ERECTA proteins and a role of the SWI3B subunit of the SWI/SNF chromatin remodeling complex in gibberellin signaling.
    3. Direct attenuation of Arabidopsis ERECTA signalling by a pair of U-box E3 ligases.
      Title: Direct attenuation of Arabidopsis ERECTA signalling by a pair of U-box E3 ligases.
    4. Spatiotemporal control of miR398 biogenesis, via chromatin remodeling and kinase signaling, ensures proper ovule development.
      Title: Spatiotemporal control of miR398 biogenesis, via chromatin remodeling and kinase signaling, ensures proper ovule development.
    5. Cantil: a previously unreported organ in wild-type Arabidopsis regulated by FT, ERECTA and heterotrimeric G proteins.
      Title: Cantil: a previously unreported organ in wild-type Arabidopsis regulated by FT, ERECTA and heterotrimeric G proteins.
    6. Modification of soybean growth and abiotic stress tolerance by expression of truncated ERECTA protein from Arabidopsis thaliana.
      Title: Modification of soybean growth and abiotic stress tolerance by expression of truncated ERECTA protein from Arabidopsis thaliana.
    7. ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity.
      Title: ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity.
    8. Study discovered SOBIR1/EVR as a regulator of secondary growth. SOBIR1/EVR acts through a mechanism that involves BREVIPEDICELLUS (BP) and ERECTA (ER). SOBIR1/EVR physically interacts with ER and that defects caused by the sobir1/evr mutation are aggravated by mutating ER, indicating that SOBIR1/EVR and ERECTA act together in the control of the precocious formation of xylem fiber development.
      Title: SOBIR1/EVR prevents precocious initiation of fiber differentiation during wood development through a mechanism involving BP and ERECTA.
    9. EDT1/HDG11-ERECTA-E2Fa genetic pathway that reduces stomatal density by increasing cell size and provide a new avenue to improve WUE of crops.
      Title: AtEDT1/HDG11 regulates stomatal density and water-use efficiency via ERECTA and E2Fa.
    10. The expression regulation of ERECTA and SPEECHLESS gene families are critical for molecular control of stomatal development. (Review)
      Title: Molecular control of stomatal development.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128190.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflorescence morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within megasporocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polarity specification of adaxial/abaxial axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of plant organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transpiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich receptor-like protein kinase family protein
    NP_180201.1
    • ERECTA (ER); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ERECTA-like 2 (TAIR:AT5G07180.1); Has 231155 Blast hits to 140492 proteins in 4172 species: Archae - 144; Bacteria - 21921; Metazoa - 82313; Fungi - 10847; Plants - 87687; Viruses - 446; Other Eukaryotes - 27797 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11208080..11214662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128190.3 → NP_180201.1  Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180201.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5YYA0, A5YYB1, Q42371, Q56WZ3
      UniProtKB/TrEMBL
      A0A178W3B8, A0A5S9X1C7
      Conserved Domains (2) summary
      PLN00113
      Location:7 → 916
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:239 → 260
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42371.1

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