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    ftsh3 FTSH protease 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817456, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ftsh3
    Official Full Name
    FTSH protease 3
    Primary source
    TAIR:AT2G29080
    Locus tag
    AT2G29080
    See related
    Araport:AT2G29080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FTSH protease 3; T9I4.16; T9I4_16
    Summary
    encodes an FtsH protease that is localized to the mitochondrion
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    Genomic context

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    See ftsh3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (12489627..12493329, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene GRAS family transcription factor Neighboring gene Ubiquitin fusion degradation UFD1 family protein Neighboring gene cytochrome P450, family 707, subfamily A, polypeptide 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly. Ivanova A, et al. Plant Physiol, 2021 May 27. PMID 33616659, Free PMC Article
    2. Identification and characterization of high molecular weight complexes formed by matrix AAA proteases and prohibitins in mitochondria of Arabidopsis thaliana. Piechota J, et al. J Biol Chem, 2010 Apr 23. PMID 20172857, Free PMC Article
    3. Chloroplast and mitochondrial proteases in Arabidopsis. A proposed nomenclature. Adam Z, et al. Plant Physiol, 2001 Apr. PMID 11299370, Free PMC Article
    4. Coordinated regulation and complex formation of yellow variegated1 and yellow variegated2, chloroplastic FtsH metalloproteases involved in the repair cycle of photosystem II in Arabidopsis thylakoid membranes. Sakamoto W, et al. Plant Cell, 2003 Dec. PMID 14630971, Free PMC Article
    5. New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy. Peltier JB, et al. J Biol Chem, 2004 Nov 19. PMID 15322131

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.
      Title: The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_179798.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    FTSH protease 3
    NP_850129.1
    • FTSH protease 3 (ftsh3); FUNCTIONS IN: ATP-dependent peptidase activity, ATPase activity; INVOLVED IN: proteolysis, protein catabolic process; LOCATED IN: mitochondrion, chloroplast thylakoid membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M41, FtsH (InterPro:IPR005936), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peptidase M41 (InterPro:IPR000642), Peptidase M41, FtsH extracellular (InterPro:IPR011546); BEST Arabidopsis thaliana protein match is: FTSH protease 10 (TAIR:AT1G07510.1); Has 42068 Blast hits to 39734 proteins in 3332 species: Archae - 1581; Bacteria - 17420; Metazoa - 4814; Fungi - 3774; Plants - 3280; Viruses - 30; Other Eukaryotes - 11169 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12489627..12493329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179798.2 → NP_850129.1  FTSH protease 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81076, Q0WWR8, Q84WU8, Q8VZR5
      UniProtKB/TrEMBL
      A0A178VS82, A0A5S9X2R1, A0A654EX55
      Conserved Domains (2) summary
      TIGR01241
      Location:259 → 758
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam06480
      Location:135 → 244
      FtsH_ext; FtsH Extracellular
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84WU8.1

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