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    ALG3 asparagine-linked glycosylation 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819388, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALG3
    Official Full Name
    asparagine-linked glycosylation 3
    Primary source
    TAIR:AT2G47760
    Locus tag
    AT2G47760
    See related
    Araport:AT2G47760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana asparagine-linked glycosylation 3; asparagine-linked glycosylation 3; AtALG3; F17A22.15
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    Genomic context

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    See ALG3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (19564795..19568438, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene putative indole-3-acetic acid-amido synthetase GH3.9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TSPO(outer membrane tryptophan-rich sensory protein)-like protein Neighboring gene Rubber elongation factor protein (REF) Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana. Trempel F, et al. BMC Plant Biol, 2016 Jan 28. PMID 26822404, Free PMC Article
    2. Arabidopsis thaliana ALG3 mutant synthesizes immature oligosaccharides in the ER and accumulates unique N-glycans. Kajiura H, et al. Glycobiology, 2010 Jun. PMID 20356820
    3. Identification of the gene encoding the alpha1,3-mannosyltransferase (ALG3) in Arabidopsis and characterization of downstream n-glycan processing. Henquet M, et al. Plant Cell, 2008 Jun. PMID 18567790, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. allelic cce2 and cce3 mutants are caused by mutations in AtALG3 (Asparagine-Linked Glycosylation 3), thereby resulting in underglycosylation of several PRRs and compromised MAMP/DAMP signaling
      Title: Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana.
    2. In ALG3 mutant, an immature lipid-linked oligosaccharide structure,ER, was synthesized, and used for protein N-glycosylation, resulting in the blockade of subsequent maturation with the concanavalin A affinoactive and Endo H-insensitive structure.
      Title: Arabidopsis thaliana ALG3 mutant synthesizes immature oligosaccharides in the ER and accumulates unique N-glycans.
    3. ALG3 mutant analysis reveals that when ALG3 activity is strongly reduced, almost all N-glycans transferred to proteins are aberrant, indicating that the Arabidopsis oligosaccharide transferase complex is remarkably substrate tolerant.
      Title: Identification of the gene encoding the alpha1,3-mannosyltransferase (ALG3) in Arabidopsis and characterization of downstream n-glycan processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001036479.1
    NM_001036480.1
    NM_001337274.1
    NM_001337275.1
    NM_130343.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-1,3-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mannosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    asparagine-linked glycosylation 3
    NP_001031556.1
    • asparagine-linked glycosylation 3 (ALG3); CONTAINS InterPro DOMAIN/s: Glycosyltransferase, ALG3 (InterPro:IPR007873); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031557.1
    • asparagine-linked glycosylation 3 (ALG3); CONTAINS InterPro DOMAIN/s: Glycosyltransferase, ALG3 (InterPro:IPR007873); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001318442.1
    • asparagine-linked glycosylation 3 (ALG3); CONTAINS InterPro DOMAIN/s: Glycosyltransferase, ALG3 (InterPro:IPR007873); Has 381 Blast hits to 338 proteins in 173 species: Archae - 2; Bacteria - 2; Metazoa - 149; Fungi - 152; Plants - 35; Viruses - 0; Other Eukaryotes - 41 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19564795..19568438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337274.1 → NP_001318442.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZE55, A0A5S9X8N8

    2. NM_001337275.1 → NP_001324356.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZV0, A0A5S9X8N8

    3. NM_001036479.1 → NP_001031556.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPN0
      Conserved Domains (1) summary
      pfam05208
      Location:37 → 400
      ALG3; ALG3 protein

    4. NM_001036480.1 → NP_001031557.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031557.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X8N8
      Conserved Domains (1) summary
      pfam05208
      Location:37 → 380
      ALG3; ALG3 protein

    5. NM_130343.4 → NP_182297.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IM37, F4IM39, O82244, Q944H6
      UniProtKB/TrEMBL
      A0A178VPN0, W8Q394
      Conserved Domains (1) summary
      pfam05208
      Location:37 → 401
      ALG3; ALG3 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82244.1

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