U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GSTF8 glutathione S-transferase phi 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819386, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GSTF8
    Official Full Name
    glutathione S-transferase phi 8
    Primary source
    TAIR:AT2G47730
    Locus tag
    AT2G47730
    See related
    Araport:AT2G47730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana glutathione S-transferase phi 8; ATGSTF5; ATGSTF8; F17A22.12; GLUTATHIONE S-TRANSFERASE (CLASS PHI) 5; GLUTATHIONE S-TRANSFERASE 16; glutathione S-transferase phi 8; GST6
    Summary
    Encodes glutathione transferase belonging to the phi class of GSTs. Naming convention according to Wagner et al. (2002).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GSTF8 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (19556326..19559485)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene NADH-ubiquinone oxidoreductase-like protein Neighboring gene RING/U-box superfamily protein Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Gly Neighboring gene putative indole-3-acetic acid-amido synthetase GH3.9 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential gene expression and subcellular targeting of Arabidopsis glutathione S-transferase F8 is achieved through alternative transcription start sites. Thatcher LF, et al. J Biol Chem, 2007 Sep 28. PMID 17670748
    2. The promoter of a H2O2-inducible, Arabidopsis glutathione S-transferase gene contains closely linked OBF- and OBP1-binding sites. Chen W, et al. Plant J, 1996 Dec. PMID 9011080
    3. The auxin, hydrogen peroxide and salicylic acid induced expression of the Arabidopsis GST6 promoter is mediated in part by an ocs element. Chen W, et al. Plant J, 1999 Sep. PMID 10571852
    4. Molecular mechanism study on the interactions of cadmium (II) ions with Arabidopsis thaliana glutathione transferase Phi8. Hou X, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2019 Jun 5. PMID 30925335
    5. The Arabidopsis glutathione transferases, AtGSTF8 and AtGSTU19 are involved in the maintenance of root redox homeostasis affecting meristem size and salt stress sensitivity. Horváth E, et al. Plant Sci, 2019 Jun. PMID 31128707

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. involved in the maintenance of root redox homeostasis affecting meristem size and salt stress sensitivity
      Title: The Arabidopsis glutathione transferases, AtGSTF8 and AtGSTU19 are involved in the maintenance of root redox homeostasis affecting meristem size and salt stress sensitivity.
    2. The intrinsic fluorescence of GSTF8 was quenched statically upon the addition of cadmium ions accompanied with the complex formation and structural and conformational alterations from multiple spectroscopic measurements, resulting in deconstructed protein skeleton and microenvironmental alterations around the Tyr and Trp residues.
      Title: Molecular mechanism study on the interactions of cadmium (II) ions with Arabidopsis thaliana glutathione transferase Phi8.
    3. alternate transcription start sites of the GSTF8 promoter are used to confer differential tissue-specific and stress-responsive expression patterns as well as to target the same protein to two different subcellular localizations.
      Title: Differential gene expression and subcellular targeting of Arabidopsis glutathione S-transferase F8 is achieved through alternative transcription start sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001337273.1
    NM_180148.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within toxin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutathione S-transferase phi 8
    NP_850479.1
    • glutathione S-transferase phi 8 (GSTF8); FUNCTIONS IN: glutathione transferase activity, glutathione binding; INVOLVED IN: in 8 processes; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Glutathione S-transferase, C-terminal (InterPro:IPR004046), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: glutathione S-transferase PHI 2 (TAIR:AT4G02520.1); Has 15602 Blast hits to 15586 proteins in 1475 species: Archae - 0; Bacteria - 9018; Metazoa - 1960; Fungi - 883; Plants - 1109; Viruses - 0; Other Eukaryotes - 2632 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19556326..19559485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180148.5 → NP_850479.1  glutathione S-transferase phi 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82242, Q4PL91, Q96266, Q9FUT2
      UniProtKB/TrEMBL
      A0A178VZN0
      Conserved Domains (3) summary
      PLN02395
      Location:58 → 260
      PLN02395; glutathione S-transferase
      cd03187
      Location:141 → 258
      GST_C_Phi; C-terminal, alpha helical domain of Class Phi Glutathione S-transferases
      cd03053
      Location:54 → 125
      GST_N_Phi; GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide ...

    2. NM_001337273.1 → NP_001323480.1  glutathione S-transferase phi 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82242, Q4PL91, Q96266, Q9FUT2
      UniProtKB/TrEMBL
      A0A178VZN0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96266.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools