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    ADT6 arogenate dehydratase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837345, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADT6
    Official Full Name
    arogenate dehydratase 6
    Primary source
    TAIR:AT1G08250
    Locus tag
    AT1G08250
    See related
    Araport:AT1G08250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana arogenate dehydratase 6; arogenate dehydratase 6; AtADT6; T23G18.10; T23G18_10
    Summary
    Encodes a plastid-localized arogenate dehydratase involved in phenylalanine biosynthesis. Although this enzyme has sequence similarity to prephenate dehydratases, it is 98 times more active with arogenate than prephenate in enzymatic assays.
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    Genomic context

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    See ADT6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (2588776..2590609, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene tRNA-Gly Neighboring gene DNA polymerase epsilon catalytic subunit Neighboring gene vacuolar protein sorting-associated protein Neighboring gene Glycosyltransferase family 29 (sialyltransferase) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis. Wang XC, et al. Plant J, 2020 Feb. PMID 31626358
    2. Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism. Höhner R, et al. Plant Physiol, 2018 May. PMID 29523714, Free PMC Article
    3. Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis. Rippert P, et al. Plant Physiol, 2009 Mar. PMID 19136569, Free PMC Article
    4. Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. Cho MH, et al. J Biol Chem, 2007 Oct 19. PMID 17726025
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis.
      Title: Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis.
    2. ADT6 role in photosynthesis and secondary metabolism.
      Title: Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_100698.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arogenate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prephenate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    arogenate dehydratase 6
    NP_563809.1
    • arogenate dehydratase 6 (ADT6); FUNCTIONS IN: arogenate dehydratase activity, prephenate dehydratase activity; INVOLVED IN: L-phenylalanine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: prephenate dehydratase 1 (TAIR:AT2G27820.1); Has 7065 Blast hits to 7063 proteins in 2215 species: Archae - 179; Bacteria - 3948; Metazoa - 2; Fungi - 121; Plants - 264; Viruses - 0; Other Eukaryotes - 2551 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2588776..2590609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100698.4 → NP_563809.1  arogenate dehydratase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563809.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SGD6
      UniProtKB/TrEMBL
      A0A178W954, A0A5S9T8Y5
      Conserved Domains (1) summary
      PLN02317
      Location:8 → 402
      PLN02317; arogenate dehydratase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SGD6.1

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