U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HYD1 C-8,7 sterol isomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838593, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HYD1
    Official Full Name
    C-8,7 sterol isomerase
    Primary source
    TAIR:AT1G20050
    Locus tag
    AT1G20050
    See related
    Araport:AT1G20050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HYDRA1; MAD4; miRNA action deficient 4
    Summary
    C-8 sterol isomerase that also plays a role in miRNA function.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HYD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (6949043..6950509)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene tRNA-Leu Neighboring gene ATP binding microtubule motor family protein Neighboring gene DNA-directed RNA polymerase I subunit RPA12-like protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sterol isomerase HYDRA1 interacts with RNA silencing suppressor P1b and restricts potyviral infection. Ochoa J, et al. Plant Cell Environ, 2019 Nov. PMID 31286514
    2. Epidermal expression of a sterol biosynthesis gene regulates root growth by a non-cell-autonomous mechanism in Arabidopsis. Short E, et al. Development, 2018 May 15. PMID 29695610, Free PMC Article
    3. Interactions between sterol biosynthesis genes in embryonic development of Arabidopsis. Schrick K, et al. Plant J, 2002 Jul. PMID 12100483
    4. Isolation and characterization of an Arabidopsis thaliana C-8,7 sterol isomerase: functional and structural similarities to mammalian C-8,7 sterol isomerase/emopamil-binding protein. Grebenok RJ, et al. Plant Mol Biol, 1998 Nov. PMID 9862498
    5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HYD1 negatively impacts the accumulation of Cucumber vein yellowing virus P1b in an agroinfiltration assay. Moreover, expression of HYD1 inhibited the infection of the potyvirus Plum pox virus, especially when antiviral RNA silencing was boosted by high temperature or by coexpression of homologous sequences.
      Title: Sterol isomerase HYDRA1 interacts with RNA silencing suppressor P1b and restricts potyviral infection.
    2. Transgenic activation of HYD1 transcription in the epidermis of hyd1 null mutants reveals a major role in root patterning and growth. HYD1 expression in the vascular tissues and root meristem, though not endodermis or pericycle, also leads to some phenotypic rescue.
      Title: Epidermal expression of a sterol biosynthesis gene regulates root growth by a non-cell-autonomous mechanism in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_101859.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables C-8 sterol isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cholestenol delta-isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    C-8,7 sterol isomerase
    NP_173433.1
    • HYDRA1 (HYD1); FUNCTIONS IN: C-8 sterol isomerase activity; INVOLVED IN: sterol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Emopamil-binding (InterPro:IPR007905); Has 377 Blast hits to 377 proteins in 112 species: Archae - 0; Bacteria - 0; Metazoa - 119; Fungi - 175; Plants - 59; Viruses - 0; Other Eukaryotes - 24 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6949043..6950509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101859.4 → NP_173433.1  C-8,7 sterol isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48962, Q9SAQ8
      UniProtKB/TrEMBL
      A0A178WKY6, A0A384KZV1, A0A5S9V9B4, Q0WRA8, Q8LDC3
      Conserved Domains (1) summary
      pfam05241
      Location:90 → 199
      EBP; Emopamil binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48962.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools