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    Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838336, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    TAIR:AT1G17600
    Locus tag
    AT1G17600
    See related
    Araport:AT1G17600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F1L3.30; F1L3_30
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (6052936..6058114, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene myosin 1 Neighboring gene nuclear factor Y, subunit A8 Neighboring gene Disease resistance protein (TIR-NBS class) Neighboring gene Disease resistance protein (TIR-NBS class) Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3. Tong M, et al. New Phytol, 2017 Sep. PMID 28691210
    2. Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3. Zhang Y, et al. New Phytol, 2017 Feb. PMID 27699788
    3. TIR-NB-LRR immune receptor SOC3 pairs with truncated TIR-NB protein CHS1 or TN2 to monitor the homeostasis of E3 ligase SAUL1. Liang W, et al. New Phytol, 2019 Mar. PMID 30317650
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. By using CRISPR/Cas9 technology, genetic analysis and biochemical assays, it was discovered that SOC3 pairs with different truncated TN proteins, CHS1 or TN2, to monitor either the disappearance or overaccumulation of SAUL1, respectively. The differential pairing results in autoimmunity with distinct morphological outcomes. [SOC3]
      Title: TIR-NB-LRR immune receptor SOC3 pairs with truncated TIR-NB protein CHS1 or TN2 to monitor the homeostasis of E3 ligase SAUL1.
    2. the E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by the SOC3.[SOC3]
      Title: E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3.
    3. This study reveals that the TN protein CHS1 interacts with the TNL protein SOC3 to modulate temperature-dependent autoimmunity.[SOC3]
      Title: Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_101622.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_173203.2
    • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, defense response, apoptosis, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: leaf whorl, leaf; EXPRESSED DURING: LP.10 ten leaves visible; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G40100.1); Has 24331 Blast hits to 16604 proteins in 714 species: Archae - 19; Bacteria - 1452; Metazoa - 3934; Fungi - 232; Plants - 17994; Viruses - 0; Other Eukaryotes - 700 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6052936..6058114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101622.3 → NP_173203.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173203.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WJH2, A0A5S9UWG8, F4I901
      Conserved Domains (2) summary
      PLN03210
      Location:1 → 976
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:798 → 820
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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